巻号一覧
22 巻, 12 号
選択された号の論文の40件中1～40を表示しています
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林 昌亮, 坂口 孝, 小澤 光1974 年 22 巻 12 号 p. 2771-2777
発行日: 1974/12/25
公開日: 2008/03/31
ジャーナル フリー^3H-A 41 304 ointment in the concentration of 0.27% was applied to the back skin of rats, and its absorption and distribution in the blood and organs and its excretion in the urine and feces were examined in the course of time. 1. Most of the total amount absorbed was excreted in the urine of male and female rats within 1-2 days after the beginning of the application and the excretion in the feces was slightly slower than in the urine. The ratio of the excreted amount in the feces to that in the urine was approximately 1 : 4. 2. There was a sex difference in the total amount of the excreted radioactivity for 7 days after the beginning of the application ; the amount in female rats was only about 60% of that in male ones. The excreted amount was decreased significantly by castration in male rats. The investigation with thin-layer chromatography. revealed that approximately half the absorbed amount of the compound was excreted unchanged in the urine and that the percentage was higher in female rats than in male ones. 3. The radioactivity began to appear in the blood from about 1 hr after the beginning of the application. The maximum radioactivity level was noted in the blood at 24 hr and in main organs at 31 hr. The radioactivity was little detected 7 days after the beginning of the application. 4. The liver and adrenal had higher radioactivity levels than other organs. In each organ the radioactivity reached its maximum 31 hr after the beginning of the application. No sex difference was noted in the distribution of this compound in the organs.抄録全体を表示PDF形式でダウンロード (785K) -
VISHNUJI RAM, HRIDVANAND PANDEY1974 年 22 巻 12 号 p. 2778-2783
発行日: 1974/12/25
公開日: 2008/03/31
ジャーナル フリーSome 1-(2, 4-dichlorophenoxy and 2, 4, 5-trichlorophenoxy) acetyl-4-arylthiosemicarbazides were prepared from corresponding chlorophenoxyacetohydrazide. The resulting thiosemicarbazides were cyclised into 1, 3, 4-thiadiazoles and 5-mercapto-1, 2, 4-triazoles under different reaction conditions. The mercapto compounds were converted into sulphides and sulphones. N'-arylidene (2, 4-dichlorophenoxy) acetohydrazides and 5-substituted-1, 3, 4-oxadiazole-2-thiones were also prepared from (2, 4-dichlorophenoxy and 2, 4, 5-trichlorophenoxy) acetohydrazides separately and were subjected to Mannich reaction. Some of these compounds were evaluated as fungicides against Aspergillus niger.抄録全体を表示PDF形式でダウンロード (649K) -
原山 尚, 長 秀連, 大谷 光昭, 犬伏 康夫1974 年 22 巻 12 号 p. 2784-2787
発行日: 1974/12/25
公開日: 2008/03/31
ジャーナル フリーThe Diels-Alder reaction of 5-methyl-2-cyclohexene-1-one (I) with butadiene was examined. It was concluded that addition of butadiene to the dienophile (I) took place from the opposite side to a secondary methyl side to give initially the cis adduct (IIb), which then epimerizes mostly to the trans derivative (IIa).抄録全体を表示PDF形式でダウンロード (541K) -
大野 [よし]曹, 住本 易子, 大志摩 三秋, 山田 正幸, 島本 次雄1974 年 22 巻 12 号 p. 2788-2795
発行日: 1974/12/25
公開日: 2008/03/31
ジャーナル フリーThe mechanism of the flocculation and deflocculation of Veegum (Montmorillonite) in an aqueous medium by polyoxyethylene hydrogenated castor oil which has a various length of polyoxyethylene chains, has been examined by adsorption isotherm, viscosity, zeta potential and contact angle measurements. Adsorption isotherms for these surfactants on Veegum showed flectional points (S-shaped) at a certain concentration of the surfactants added. The maximum flocculation occurred around the flectional points accompanying high viscosity in the suspension, and the measurement of contact angles showed that the Veegum surface at these points was most hydrophobic. These results suggest that the maximum flocculation occurs when all the Veegum surfaces are covered by surfactants orientating the hydrocarbon chains toward the solution, which renders the surface more hydrophobic. The deflocculation caused by the further addition of the surfactants is interpreted as being due to the bimolecular layer adsorption of the surfactants by van der Waals forces or by hydrophobic bonding between the Veegum particles adsorbed surfactants monomolecularly and the surfactants added.抄録全体を表示PDF形式でダウンロード (1006K) -
伊藤 磯雄, 永井 慎一1974 年 22 巻 12 号 p. 2796-2802
発行日: 1974/12/25
公開日: 2008/03/31
ジャーナル フリーSyntheses of 1-methyl-2-phenyl-1, 2, 3, 4, 5-pentahydro-10H-benzo[5, 6]cyclohepta[1, 2-c]pyrazole-3, 10-dione (3a) and its aminoalkylidene derivatives (3b-d) were investigated. Treatment of 3a with N-bromosuccinimide gave 4 (5)-bromo-1-methyl-2-phenyl-1, 2, 3-trihydro-10H-benzo[5, 6]cyclohepta[1, 2-c]pyrazole-3, 10-dione (13), while reaction of 3a with N-chlorosuccinimide produced 2-phenyl-2, 3, 3a, 4, 5-pentahydro-10H-benzo[5, 6]cyclohepta[1, 2-c]pyrazole-3, 10-dione (15). Dehydrogenation of 3a at 310°with palladium on carbon catalyst afforded 1-methyl-2-phenyl-1, 2, 3-trihydro-10H-benzo[5, 6]cyclohepta[1, 2-c]pyrazole-3, 10-dione (18) in a trace.抄録全体を表示PDF形式でダウンロード (856K) -
松田 芳久, 城本 純子, 武田 洋子, 林 信一, 岡田 寿太郎1974 年 22 巻 12 号 p. 2803-2811
発行日: 1974/12/25
公開日: 2008/03/31
ジャーナル フリーA new mixing index based on Hunter's color difference formula was applied to the three-component mixing of antipyrin, lactose and lactose colored with pigment (tracer powder of antipyrin). The mixing was conducted in a twin-shell mixer. The scale of scrutiny of this index was comparable with that of the mixing index used for the active ingredient. The concept of the uneven coloration is useful to follow the progress of mixing and to confirm the complete mixing. The relationship between the behavior of the active ingredient and tracer powder in the earlier stages of mixing was examined by the separate determination of antipyrin and pigment.抄録全体を表示PDF形式でダウンロード (883K) -
小林 義郎, 熊懐 稜丸, 佐藤 治男1974 年 22 巻 12 号 p. 2812-2817
発行日: 1974/12/25
公開日: 2008/03/31
ジャーナル フリーSelective protonation of 1, 6-naphthyridine and its N-oxides was studied from the results of ultraviolet spectra in various concentrations of sulfuric acid. Nitrogen atom in 6-position was protonated preferentially to that in 1-position, which seems to be caused by the stability of 2, 6-quinonoid structure. This point is also supported by the difference in the changes of effective nuclear charges on protonation, which are calculated by SCF-LCAO-MO method. It was also shown that protonation plays an important role in N-oxidation of some heteroaromatic amines with a peracid.抄録全体を表示PDF形式でダウンロード (626K) -
高見沢 映, 原田 紘1974 年 22 巻 12 号 p. 2818-2823
発行日: 1974/12/25
公開日: 2008/03/31
ジャーナル フリーReaction of thiamine analogues lacking the 5-hydroxyethyl group (6a-e) with diethyl benzoylphosphonate (7) was carried out. Comparison of reactivity in 4'-substituted thiamine analogues and those lacking the hydroxyethyl group suggests the presence of an interaction in the thiamine molecule between the pyrimidine ring and the hydroxyethyl group in an aprotic solvent. Reactivity at the 2 position (the active center in enzymatic decarboxylation) in 4'-substituted thiamine analogues may be affected by this interaction.抄録全体を表示PDF形式でダウンロード (697K) -
阿部 達也, 神戸川 明1974 年 22 巻 12 号 p. 2824-2829
発行日: 1974/12/25
公開日: 2008/03/31
ジャーナル フリーTen metabolites of 17α-acetoxy-6-chloro-4, 6-pregnadiene-3, 20-dione were isolated from urine and bile of the rabbit and their chemical structures were determined. The urinary main metabolite was 17α-acetoxy-2ξ, 3ξ-dihydroxy-5ξ-pregnan-20-one. The biliary main metabolite was 17α-acetoxy-6-chloro-2ξ, 3ξ-dihydroxy-4, 6-pregnadien-20-one. The administered compound was metabolized through two courses, one was oxidation at C-2 and another was dechlorination at C-6, in the rabbit. A small amount of the metabolite oxidized at C-21 was identified from urine.抄録全体を表示PDF形式でダウンロード (745K) -
上野 芳夫, 島田 紀子, 矢ケ崎 しげ子, 榎本 真1974 年 22 巻 12 号 p. 2830-2835
発行日: 1974/12/25
公開日: 2008/03/31
ジャーナル フリーZearalenone produced by the fungus Fusarium roseum (Gibberella zeae) caused a marked uterotrophic response in mice and rats. Single or repeated administrations to immature mice and rats resulted in an increase of the uterine weight several times higher than the control weight. This effect was specific to the uterus, and oral administration was more effective than other routes. Ovariectomized mice were highly sensitive to zearalenone, and the dose-response curve was linear when daily doses of 1 to 2 mg/kg were given for one week. Zearalenone promoted cellular proliferation and mitosis in the uterine muscle cells.抄録全体を表示PDF形式でダウンロード (889K) -
菅野 毅, 河津 光高1974 年 22 巻 12 号 p. 2836-2850
発行日: 1974/12/25
公開日: 2008/03/31
ジャーナル フリーReaction of methyl 5-O-tosyl-2, 3-O-isopropylidene-β-D-ribofuranoside (1) with the sodium salts of purines, (2) and (3), and pyrimidines, (12), (13), and (14) derivatives in DMF afforded the corresponding "reversed nucleosides". 6-Alkylaminopurine analogues were prepared by the reaction of the 6-methylthiopurine derivative (4) with the amines. After removal of the protective groups, the reversed nucleosides were oxidized by oxygen in dilute alkaline solution to afford easily eritadenine analogues as major products.抄録全体を表示PDF形式でダウンロード (1720K) -
菅野 毅, 河津 光高1974 年 22 巻 12 号 p. 2851-2860
発行日: 1974/12/25
公開日: 2008/03/31
ジャーナル フリーReaction of 5-O-tosyl-3-benzyloxycarbonylamido-3-deoxy-1, 2-O-isopropylidene-α-D-ribofuranose (21) or 5-O-tosyl-3-acetamido-3-deoxy-1, 2-O-isopropylidene-α-D-ribofuranose (30) with the sodium salt of adenine afforded the corresponding isomeric "reversed nucleosides" in good yields. Hydrolysis of the masked compound (22) followed by hydrogenolysis afforded 5-(6-aminopurin-9H-9-yl)-3-amino-3, 5-dideoxy-D-ribofuranose (26) hydrochloride in a good yield. After removal of the protective group, oxidation of 5-(6-aminopurin-9H-9-yl)-3-acetamido-3, 5-dideoxy-D-ribofuranose (33) by oxygen in a dilute alkaline solution afforded sodium 4-(6-aminopurin-9H-9-yl)-3(R)-hydroxy-2(R)-acetamidobutyrate (34). To evaluate the biological activities, amino ester (35) and amino acid (38) were also synthesized.抄録全体を表示PDF形式でダウンロード (1230K) -
松本 善雄, 武部 良久, 須賀 哲弥, 新延 信吉1974 年 22 巻 12 号 p. 2861-2865
発行日: 1974/12/25
公開日: 2008/03/31
ジャーナル フリーThe intralobular distribution of 3H-labeled p-biphenylmethyl-(dl-tropyl-α-tropinium)-bromide (3H-BTTB) and the effect of CCl4-injury on its distribution were studied in mice mainly by means of microautoradiographic technique. It was established that 3H-BTTB was mostly concentrated in the cytoplasm of hepatic parenchymal cells and that this drug distributed homogeneously over whole the intralobular area. In CCl4-treated mice, uptake of 3H-BTTB was markedly decreased in the liver and, on the other hand, was apparently increased in the kidney. In addition, the decrease in the uptake of this drug by CCl4-treated liver occurred widely within the liver lobules and more significant decreases were found especially in the central zones of lobule. During the course of preparation of microautoradiographic tissue sections, the degree of released radioactivity in CCl4-treated livers was inclined to increase than that of the controls.抄録全体を表示PDF形式でダウンロード (1032K) -
日野 亨, 佐藤 忠夫1974 年 22 巻 12 号 p. 2866-2874
発行日: 1974/12/25
公開日: 2008/03/31
ジャーナル フリーReaction of 3, 6-diethoxycarbonyl-1, 4-dimethyl-2, 5-piperazinedione (15), prepared by heating of diethyl methylaminomalonate (14), with NaH in dioxane and followed treatment with S2Cl2 gave 3, 6-epidithio- and 3, 6-epitetrathio-3, 6-diethoxycarbonyl-1, 4-dimethyl-2, 5-piperazinediones (16b and 16d), which have the skeletone (1) observed in fungal metabolites such as sporidesmin. The reduction of 16 with NaBH4 in methanol gave the dethio derivative (15) in good yield. The reaction of 16d with triphenylphosphine in tetrahydrofurane gave 16c and 16b. The reaction of diethyl malonate derivatives (23a, b, and c) with NaH and S2Cl2 in dioxane gave the corresponding disulfides or trisulfides (24a, b, and c). Some reactions of proline anhydride (5) and sarcosine anhydride (7) with S2Cl2 or sulfur were examined.抄録全体を表示PDF形式でダウンロード (1092K) -
古川 潮, 吉田 孝利, 林 清五郎1974 年 22 巻 12 号 p. 2875-2882
発行日: 1974/12/25
公開日: 2008/03/31
ジャーナル フリーThe reactions of arylbiguanides with isatin and with 1-methylisatin gave 2-oxo-3-arylbiguanidylidene-indoles and 4-amino-6-arylamino-2-(1'-methyl-2'-oxo-3'-indolidene)-1, 2-dihydro-s-triazines, respectively. Analogously, N-amidino-O-alkylisoureas reacted with isatin and 1-methylisatin to afford 2-oxo-3-alkoxyamidinoamidinylidene-indoles and 4-amino-6-alkoxy-2-(1'-methyl-2'-oxo-3'-indolidene)-1, 2-dihydro-s-triazines, respectively. The structures of these compounds were discussed.抄録全体を表示PDF形式でダウンロード (810K) -
福田 英臣, 伊藤 継孝, 小久保 実1974 年 22 巻 12 号 p. 2883-2888
発行日: 1974/12/25
公開日: 2008/03/31
ジャーナル フリーThe decerebrate rigidity in rats was prepared by means of transection between the inferior and superior colliculi. The strength of the rigidity was measured as electromyographic (EMG) activity of the rigid gastrocnemius muscle. Because of some similarity between Parkinsonism and intercollicular decerebrate rigidity, the effects of several antiparkinsonism drugs as well as centrally acting muscle relaxants on this type of the rigidity were studied. A small dose of chlorpromazine (125 μg/kg, i.v.) markedly reduced the rigidity. The inhibitory effect of trihexyphenidyl, biperiden, orphenadrine and tigloidine injected intravenously was dose-related. L-Dopa exerted only a little effect on the EMG activity of the rigid muscle. Mephenesin, methocarbamol, tolperisone, phenprobamate and diazepam were all effective in reducing the rigidity. These results are discussed in relation to data on their effects upon the crossed extensor reflexes in spinal chicks.抄録全体を表示PDF形式でダウンロード (711K) -
水野 義久, 池田 一芳1974 年 22 巻 12 号 p. 2889-2893
発行日: 1974/12/25
公開日: 2008/03/31
ジャーナル フリーAlkylation of the thiols, p-thiocresol, 4-thiouridine, 4-thiouracil, 2-mercaptoinosine, cysteine, and glutathione with 2-picolyl chloride 1-oxide (15) afforded the corresponding 2-picolyl 1-oxide derivatives (6-14) in fair to good yields even in aqueous solution. Especially, this new thiol reagent was found to work well with 4-thiouridine and glutathione. 1-Oxido-2-picolylthio-derivative (8) was subjected to deblocking of the protecting group. Recovery of 2', 3'-O-isopropylidene 4-thiouridine (19) after deblocking was found to be quite satisfactory (79.2% yield).抄録全体を表示PDF形式でダウンロード (673K) -
金子 千里, 土屋 隆, 井下田 浩1974 年 22 巻 12 号 p. 2894-2897
発行日: 1974/12/25
公開日: 2008/03/31
ジャーナル フリー1-Methylpyridazinium salts, derived from pyridazines (Ia-f), were reduced with sodium borohydride to give the corresponding 1-methyl-1, 6-dihydropyridazines (IIa-f) in 40-60% yields. Then, pyridazines (I) were reduced with sodium borohydride in the presence of methyl chloroformate to afford 1-methoxycarbonyl-1, 6-dihydropyridazines (IV) and their 1, 4-isomers (V), in total 35-65% yields, ratio of which depended on the kinds of the substituents.抄録全体を表示PDF形式でダウンロード (603K) -
山崎 和男, 藤田 規久子, 坂本 美保子, 岡田 和子, 吉田 紀代, 田中 治1974 年 22 巻 12 号 p. 2898-2902
発行日: 1974/12/25
公開日: 2008/03/31
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坂本 治雄, 杉本 昭子, 金子 主税1974 年 22 巻 12 号 p. 2903-2909
発行日: 1974/12/25
公開日: 2008/03/31
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仲井 由宣, 中島 新一郎, 柿沢 英則1974 年 22 巻 12 号 p. 2910-2915
発行日: 1974/12/25
公開日: 2008/03/31
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恩田 政行, 根田 八重子, 成松 由紹, 田中 晴雄, 粟谷 寿一, 大村 智1974 年 22 巻 12 号 p. 2916-2920
発行日: 1974/12/25
公開日: 2008/03/31
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千田 重男, 広田 耕作1974 年 22 巻 12 号 p. 2921-2928
発行日: 1974/12/25
公開日: 2008/03/31
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木下 俊夫, 飯沼 文夫, 辻 章夫, 森口 郁生1974 年 22 巻 12 号 p. 2929-2934
発行日: 1974/12/25
公開日: 2008/03/31
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石黒 伊三雄, 篠原 力雄, 石倉 明弘, 内藤 純子1974 年 22 巻 12 号 p. 2935-2940
発行日: 1974/12/25
公開日: 2008/03/31
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杉浦 衛, 伊東 晃1974 年 22 巻 12 号 p. 2941-2946
発行日: 1974/12/25
公開日: 2008/03/31
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Studies on Ketene and Its Derivatives. LXVI. Reaction of Acetoacetamide with α, β-Unsaturated Esters加藤 鉄三, 野田 昌樹1974 年 22 巻 12 号 p. 2947-2952
発行日: 1974/12/25
公開日: 2008/03/31
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杉浦 衛, 伊東 晃, 小木曽 太郎, 加藤 憲二1974 年 22 巻 12 号 p. 2953-2958
発行日: 1974/12/25
公開日: 2008/03/31
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野原 昭, 梅谷 友信, 鵜川 清, 三野 安1974 年 22 巻 12 号 p. 2959-2965
発行日: 1974/12/25
公開日: 2008/03/31
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横山 和正, 鈴木 章, 内海 勇, 内藤 良一1974 年 22 巻 12 号 p. 2966-2971
発行日: 1974/12/25
公開日: 2008/03/31
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関口 慶二, 津田 泰之, 菅家 甫子1974 年 22 巻 12 号 p. 2972-2978
発行日: 1974/12/25
公開日: 2008/03/31
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相浦 真人, 金岡 祐一1974 年 22 巻 12 号 p. 2979-2981
発行日: 1974/12/25
公開日: 2008/03/31
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田村 真造, 矢部 恵美子1974 年 22 巻 12 号 p. 2982-2986
発行日: 1974/12/25
公開日: 2008/03/31
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古川 潮, 加藤 聖子, 林 清五郎1974 年 22 巻 12 号 p. 2987-2990
発行日: 1974/12/25
公開日: 2008/03/31
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金庭 延慶, 池川 明子1974 年 22 巻 12 号 p. 2990-2998
発行日: 1974/12/25
公開日: 2008/03/31
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的場 勝英, 山崎 高應1974 年 22 巻 12 号 p. 2999-3001
発行日: 1974/12/25
公開日: 2008/03/31
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南原 利夫, 倉田 素子, 後藤 順一1974 年 22 巻 12 号 p. 3002-3005
発行日: 1974/12/25
公開日: 2008/03/31
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北川 勲, 今倉 康宏, 林 輝明, 吉岡 一郎1974 年 22 巻 12 号 p. 3009-3010
発行日: 1974/12/25
公開日: 2008/03/31
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北川 勲, 吉川 雅之, 吉岡 一郎1974 年 22 巻 12 号 p. 3010-3013
発行日: 1974/12/25
公開日: 2008/03/31
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坂井 進一郎, 新間 信夫1974 年 22 巻 12 号 p. 3013-3016
発行日: 1974/12/25
公開日: 2008/03/31
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