巻号一覧
21 巻, 10 号
選択された号の論文の39件中1～39を表示しています
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古川 潮, 杉田 亮, 小島 洋子, 林 清五郎1973 年 21 巻 10 号 p. 2099-2104
発行日: 1973/10/25
公開日: 2008/03/31
ジャーナル フリーReaction of 2, 3-epoxypropyl phenyl ether with equivalents of aromatic aldoximes and hydrazones in which the difunctional group, the carbon-nitrogen double bond adjacent to the active hydrogen group, is involved in the molecule was attempted in the presence of Lewis acid catalyst. In the result, the 1 : 1 adduct formed by the addition of the epoxide to the active hydrogen group was obtained as the only product, no trace of any cycloaddition product of the epoxide to the carbon-nitrogen double bond being isolated. The structure of the adduct was also discussed.抄録全体を表示PDF形式でダウンロード (694K) -
田村 眞浩, 矢部 恵美子1973 年 21 巻 10 号 p. 2105-2111
発行日: 1973/10/25
公開日: 2008/03/31
ジャーナル フリーThe limitations of Combes reaction were reinvestigated. 4-(p-Chloroanilino)-3-penten-2-one (III), hitherto believed to be insusceptible to cyclodehydration in sulfuric acid, reacted at a higher temperature to give 2, 4-dimethyl-6-chloroquinoline (IV). 4-Anilino-3-buten-2-one (V), however, was sulfonated in concentrated sulfuric acid and no quinolines were detected in the reaction mixture. 4-(p-Chloroanilino)-3-buten-2-one (VI) was cyclodehydrated to give 6-chloroquinaldine (VIII) in dioxane containing sulfuric acid in low yield. β-Anilinoacrolein (X), a pussible reactant of Combes reaction, and its derivatives were synthesised for further studies, and their structure was confirmed by chemical evidences and by their infrared and nuclear magnetic resonance (NMR) spectra. The conformational analysis of β-arylaminoacroleins in three solvents was carried out using their NMR spectra.抄録全体を表示PDF形式でダウンロード (775K) -
大谷 元治, 山田 俊一1973 年 21 巻 10 号 p. 2112-2118
発行日: 1973/10/25
公開日: 2008/03/31
ジャーナル フリーAlkylation of enamines prepared from 2-phenylpropanal and L-proline derivatives, with methyl vinyl ketone, was successful and gave, after hydrolysis and cyclization, optically active (+)-4-methyl-4-phenyl-2-cyclohexanone ((+)-IV). The effects of L-proline derivatives, solvents, and reaction temperature on the alkylation were discussed. Under selected conditions the optical yield reached about 50%. Asymmetric induction was clearly thermodynamically controlled.抄録全体を表示PDF形式でダウンロード (800K) -
大谷 元治, 山田 俊一1973 年 21 巻 10 号 p. 2119-2124
発行日: 1973/10/25
公開日: 2008/03/31
ジャーナル フリー(+)-4-Methyl-4-phenyl-2-cyclohexenone ((+)-I), obtained by asymmetric synthesis, was chemically correlated to (S)-(+)-2-methyl-2-phenylbutanoic acid, whose absolute configuration is known. It was shown that (+)-4-methyl-4-phenyl-2-cyclohexenone ((+)-I) has (R) configuration. In determining the configuration, the optical ratation of optically pure (+)-4-methyl-4-phenyl-2-cyclohexenone ((+)-I) was estimated to be +130°in ethanol at D ray.抄録全体を表示PDF形式でダウンロード (896K) -
大谷 元治, 山田 俊一1973 年 21 巻 10 号 p. 2125-2129
発行日: 1973/10/25
公開日: 2008/03/31
ジャーナル フリーEnamines III, prepared from some disubstituted acetaldehydes I and L-proline pyrrolidide (II), were alkylated with methyl vinyl ketone to generally afford optically active 4, 4-disubstituted 2-cyclohexenones V. This asymmetric synthesis is found to be widely applicable, their absolute configurations could be deduced by a comparison of the two substituents.抄録全体を表示PDF形式でダウンロード (682K) -
大谷 元治, 山田 俊一1973 年 21 巻 10 号 p. 2130-2135
発行日: 1973/10/25
公開日: 2008/03/31
ジャーナル フリーAsymmetric synthesis of 4, 4-disubstituted 2-cyclohexenone with enamine alkylation was successfully applied to the total synthesis of (+)-mesembrine. The assignment of the absolute configuration for synthetic (+)-mesembrine was consistent with the configuration of natural (-)-mesembrine determined by X-ray crystallography.抄録全体を表示PDF形式でダウンロード (816K) -
堀越 勇, 竹口 紀晃, 森井 孫俊, 佐野 明美1973 年 21 巻 10 号 p. 2136-2140
発行日: 1973/10/25
公開日: 2008/03/31
ジャーナル フリーThe concentration and the distribution of stress by compression with several different pressures in convex type tablets were studied, measuring specific enzyme activities of proteinase as a parameter. As for the parts where stress center, a new zone which gives worse damages to the enzyme activity was found that appeared about two third from the center of tablets in the longitudinal direction. And the new zone was related to structural breakings in the experiment of compression of large two dimensional model. It was estimated that Lamination is closely related to the recovery of elastic deformation at the new zone and that Capping is related to that at upper corners. The new zone was proposed by authors to be called the L zone for its close relation to the phenomenon of Lamination.抄録全体を表示PDF形式でダウンロード (729K) -
林 時司, 八木 千恵子, 大垣 進司, 河合 聡, 大野 武男1973 年 21 巻 10 号 p. 2141-2145
発行日: 1973/10/25
公開日: 2008/03/31
ジャーナル フリーAn attempt was made to develop a sensitive and selective method for the determination of phosphate utilizing the quenching of fluorescence of 3-hydroxy-3', 4'-dimethoxyflavone-magnesium chelate by phosphate ion, after selective extraction of phosphate as phosphomolybdic acid from other interfering ions. A new fluorometric method was thereby established for the determination of phosphate which is useful for urinary phosphate assay.抄録全体を表示PDF形式でダウンロード (586K) -
鈴江 清吾, 広部 雅昭, 岡本 敏彦1973 年 21 巻 10 号 p. 2146-2160
発行日: 1973/10/25
公開日: 2008/03/31
ジャーナル フリー2-Alkyl-3-acyloxypyrazolo [1, 5-a] pyridines (III) were prepared by refluxing 1-amino-2-hydroxymethylpyrioinium chloride (Ia) in excess acyl anhydride in the presence of a base. III were converted into 2-alkyl-3-hydroxy derivatives (IVa-f) by acid hydrolysis. Ia was refluxed with ethyl orthoformate in acetic acid containing sodium acetate to give 3-hydroxy derivative (IVg). Reaction of Ia with benzoyl chloride in H2O-K2CO3 gave mainly O, N-dibenzoyl ylide (VIIa) and 2-phenyl-3-benzoyloxypyrazolo [1, 5-a] pyridine (IXa). Pyrolysis of VIIa gave 2-phenyl-3-hydroxy derivative (VIIIa), which was also obtained from 1-ben-zimido-2-hydroxymethylpyridine (VIa) by treatment with H2SO4, followed by alkali treatment. Further the compound (VIIIa) was prepared by the reaction of 1-benzimido-2-picoline (XVIIa) with I2 in pyridine. Analogously various 2-substituted-3-hydroxy derivatives (VIIIb-1 and IVa) were obtained. 1-Anilinothiocarbonylimino-2-hydroxymethylpyridine (XIXa) was converted into cyclic pyridinium salt (XXa) by treating with H2SO4, and XXa was treated with K2CO3 to give 2, 2'-dianilinopyrazolo [1, 5-a] pyridine-3, 3'-disulfide (XXIIa). XXIIa was converted into 2-anilino derivative (XXIIIa) by Raney Ni reduction. Analogously 2-benzamido derivative (XXIIIb) was obtained from 1-benzamidothiocarbonylimino-2-hydroxymethylpyridine (XIXa) by the same procedure. 2-Acetamido derivative (XXIX) was obtained by heating pyridine-2-acetamidoxime (XXVII) with acetic anhydride. The compounds (XXIIIa and XXIX) were also converted into the corresponding 3-thiocyano and 3-nitro derivatives (XXIV, XXV, XXXIb and XXXIc). The tuberculostatic activities of the pyrazolo [1, 5-a] pyridine derivatives were also indicated.抄録全体を表示PDF形式でダウンロード (1507K) -
内海 勇, 河野 啓一, 竹内 由和1973 年 21 巻 10 号 p. 2161-2167
発行日: 1973/10/25
公開日: 2008/03/31
ジャーナル フリーThe mechanism of the action of sodium glycocholate (SGC), which resulted in disappearance of the inhibitory effect of sodium laurylsulfate (SLS) on the absorption of benzoylthiamine disulfide (BTDS) from rat intestine, was investigated. It was observed that membrane altering action of SGC did not contribute to the antagonistic effect of SGC against SLS, as determined by circulation experiments with BTDS after precirculation with or without SGC in the presence or absence of SLS through rat small intestine. However, studies as to the physico-chemical behaviour of BTDS such as micellar partitioning in the solution of SLS, SGC and their mixture revealed that the effect of SGC on the BTDS absorption in the presence of SLS was due to the formation of the mixed micelles, which resulted in an increase in the amount of BTDS out of the micelles. In contrast of SLS, polysorbate 80 did not show any apparent changes in the characteristic of the micelles in the presence of SGC. This finding was quite agreeable with the in situ absorption experiment of BTDS.抄録全体を表示PDF形式でダウンロード (800K) -
壁屋 豊繁, 小橋 一弥, 大倉 洋甫, 百瀬 勉1973 年 21 巻 10 号 p. 2168-2174
発行日: 1973/10/25
公開日: 2008/03/31
ジャーナル フリーColor reaction of picric acid with acetone in an aqueous alkaline solution under the Janovsky conditions was investigated. Two main coloring matters responsible for the observed colors were prepared separately and their chemical structures were determined as a Meisenheimer compound (I-2Na) and a bicyclic compound (II-Na), respectively, as shown in Chart 2 and 3. The correlation between the coloring matters and their roles in the reaction were discussed by comparing the spectral behavior of them with the spectral changes of the reaction mixture.抄録全体を表示PDF形式でダウンロード (831K) -
村田 正弘, 北村 公一, 馬場 義彦, 渡辺 宏1973 年 21 巻 10 号 p. 2175-2182
発行日: 1973/10/25
公開日: 2008/03/31
ジャーナル フリーCytochromes c from two strains of yeast, Saccharomyces oviformis M2 (M2-cyt. c) and Candida krusei, in their cross-reactivities against their antibodies, were investigated by various methods. The results indicated that cytochromes c from these two yeasts cross-reacted each other with their antibodies, but that horse heart cytochrome c did not cross-react. It was also suggested that the passive cutaneous anaphylaxis inhibition test is preferable to the usual in vitro methods in detecting slight difference in the cross-reactivities between closely related antigens. Another experiments using peptide fragments obtained by enzymatic or chemical cleavage of M2-cyt. c showed that P-4 and P-7 were found to fix complements, and P-3, P-4, P-5 and P-6 eliminated the inhibitory effect of the antibody against the enzymatic reaction of cytochrome c-cytochrome oxidase.抄録全体を表示PDF形式でダウンロード (946K) -
島田 和武, 藤井 洋一, 南原 利夫1973 年 21 巻 10 号 p. 2183-2186
発行日: 1973/10/25
公開日: 2008/03/31
ジャーナル フリーIn order to examine the physiological activity the arginine-linked cardiotonic steroids have been synthesized as bufotoxin analogs. Resibufogenin 3-suberoyl-p-nitrophenyl ester, derivable from the 3-suberate, was condensed with L-arginine hydrochloride to yield resibufogenin 3-suberoyl-L-arginine. In an analogous manner digitoxigenin 3-suberate was converted into 3-suberoyl-L-arginine, -L-arginyl-L-arginine and -L-arginyl-L-proline via the activated p-nitrophenyl ester. The structure of the product was verified by leading to the pyrimidine derivative, respectively.抄録全体を表示PDF形式でダウンロード (606K) -
小橋 一弥, 壁屋 豊繁, 大倉 洋甫, 百瀬 勉1973 年 21 巻 10 号 p. 2187-2194
発行日: 1973/10/25
公開日: 2008/03/31
ジャーナル フリーTwo main coloring matters were isolated in crystalline forms from an aqueous reaction mixture of acetophenone and 1, 3, 5-trinitrobenzene under the Janovsky conditions. One of them was the Meisenheimer type compound, sodium salt of II. The other was a new compound and the structure was determined as sodium salt of diphenacyltrinitrocyclohexenide anion III (Chart 3). The spectral behavior of these coloring matters was compared with that of the reaction mixture and the color reaction of acetophenone and TNB under the aqueous Janovsky conditions was discussed.抄録全体を表示PDF形式でダウンロード (834K) -
吉岡 晃一, 朝子 典彦, 後藤 義一, 平賀 謙太郎, 三木 卓一1973 年 21 巻 10 号 p. 2195-2201
発行日: 1973/10/25
公開日: 2008/03/31
ジャーナル フリーdl-17α-Ethynyl-17β-hydroxy-13β-allylgon-4-en-3-one (XXIV) was synthesized via 17β, 2'-epoxy pentaene (X). The double bonds at C-14 and -8 of X was hydrogenated sequentially by conventional methods. 17β, 2'-Epoxy triene (XIII) was treated with p-toluenesulfonic acid in acetic anhydride to give 13β-allylgonane (XIV) as a major product. Birch reduction of the tetrahydropyranyl ether (XIX) followed by acid treatment yielded the 4-en-3-one compound (XXI), which was oxidized with chromium trioxidepyridine complex to the 17-ketone (XXII). The enol ether (XXIII) was treated with lithium acetylide in ethylenediamine, and then with acid to yield XXIV. The progestational activity of XXIV is as potent as norgestrel.抄録全体を表示PDF形式でダウンロード (899K) -
吉岡 晃一, 後藤 義一, 平賀 謙太郎, 三木 卓一1973 年 21 巻 10 号 p. 2202-2208
発行日: 1973/10/25
公開日: 2008/03/31
ジャーナル フリーIn order to protect selectively the double bond of the allyl group at C-13 in 3-methoxy-13-allyl-8, 14-secogona-1, 3, 5 (10), 9-tetraene-14, 17-dione (I), the authors established the synthesizing route via 9α, 14α-epoxy-3-methoxy-13β-allyl-8, 14-secogona-1, 3, 5 (10)-trien-17-one (IV), which was converted into the diol (VI) or the dibromide (XXVI). Reaction of VI with acetic anhydride and p-toluenesulfonic acid gave the gonapentaene triacetate (X), but treatment of VI with hydrochloric acid in methanol yielded a novel steroid (VIII).抄録全体を表示PDF形式でダウンロード (909K) -
南原 利夫, 後藤 順一1973 年 21 巻 10 号 p. 2209-2212
発行日: 1973/10/25
公開日: 2008/03/31
ジャーナル フリーIn order to examine the physiological activity C-17 epimeric 5α, 13α-cardenolides have been synthesized from 3β-hydroxy-5α, 13α-pregnan-20-one acetates (I, VII). Condensation with lithium ethoxyacetylide gave rise to the ethoxyacetylenic carbinols (V, VIII), respectively. Being exposed to sulfuric acid these carbinols underwent easily rearrangement to form the α, β-unsaturated esters (IVa, IXa). Subsequent treatment with selenium dioxide effected oxidation followed by intramolecular condensation resulting in formation of the butenolide ring. Hydrolytic cleavage of the 3-acetates (VIb, Xb) with methanolic hydrochloric acid afforded the desired 3β-hydroxy-5α, 13α-card-20 (22)-enolides (VIa, Xa).抄録全体を表示PDF形式でダウンロード (570K) -
K.A. WATANABE, J.J. FOX1973 年 21 巻 10 号 p. 2213-2216
発行日: 1973/10/25
公開日: 2008/03/31
ジャーナル フリーA"hybrid"which contains the nucleoside moiety of blasticidin S and the dipeptide group of Gougerotin was synthesized by step-wise linkage of sarcosine and D-serine to cytosinine using the dicyclohexylcarbodeimide (DCC) procedure.抄録全体を表示PDF形式でダウンロード (541K) -
岡田 幸蔵, 上原 隆, 平本 実, 加藤 久雄, 鈴木 友二1973 年 21 巻 10 号 p. 2217-2223
発行日: 1973/10/25
公開日: 2008/03/31
ジャーナル フリーThe amino acid sequences of the three bradykinin-potentiating peptides from the venom of Agkistrodon halys blomhoffii (potentiators B, C, and E), which had been previously presented by Kato and Suzuki using conventional stepwise techniques, were smoothly confirmed by means of mass spectrometry coupled with enzymatic cleavage techniques. In the course of the sequencing, it was suggested that the preparation of potentiator B previously purified is contaminated by a small amount of the peptides with analogous amino acid sequences. The results showed the usefulness of mass spectrometric method in the sequence determination of naturally occurring peptides having N-terminal pyroglutamic acid and abundant proline residues. Mass spectrometric method was also effective for the detection of a small amount of contaminating peptide in the sample.抄録全体を表示PDF形式でダウンロード (825K) -
平井 健太郎, 杉本 裕彦1973 年 21 巻 10 号 p. 2224-2230
発行日: 1973/10/25
公開日: 2008/03/31
ジャーナル フリーThe influence of the contribution of the dipolar form to the resonance hybrid structure on the chemical stability of 1, 3-dithiol- and oxathiol-2-ylidene derivatives was investigated by means of infrared, ultraviolet, nuclear magnetic resonance, and dipole moment measurement. It is concluded that though the contribution of the polar form to the resonance hybrid is small, it is nevertheless important for double bond isomerization through nonbenzenoid aromatic stabilization of its positive charge. Protonation of the double bond in acid medium does not necessarily occur, since some of the title compounds are not Hammett bases.抄録全体を表示PDF形式でダウンロード (751K) -
吉村 英敏, 山本 弘明, 佐伯 清太郎1973 年 21 巻 10 号 p. 2231-2236
発行日: 1973/10/25
公開日: 2008/03/31
ジャーナル フリーIn order to understand the toxic nature of Kanechlor-400 (KC-400, a commercial preparation of polychlorinated biphenyls) and establish the treatment of the patients of this KC-400 intoxication (so-called Yusho), metabolic fate of 2, 4, 3', 4'-tetrachlorobiphenyl (2, 4, 3', 4'-TCB), a major component of KC-400, was investigated using rats. It was found that at least four metabolites having phenolic nature were excreted exclusively into the feces together with a large amount of unchanged 2, 4, 3', 4'-TCB. Among these, a major metabolite (M-A2), mp 155-156°, and a minor metabolite (M-A1), mp 92-98°, were isolated from the feces and characterized to be monohydroxylated TCB by ultraviolet, infrared, nuclear magnetic resonance, and mass spectral analyses. After 2, 4, 3', 4'-TCB was orally administered at a single dose of 25 mg/body to the rat, a little less than one half of the dose was excreted as unchanged 2, 4, 3', 4'-TCB during 12 days, most of which were eliminated in the first day. The excretion of major metabolite reached maximum at the second day, and total M-A2 was accounted for about 10% of dose during 12 days. Both 2, 4, 3', 4'-TCB and its major metabolite were still excreted in a small but significant amount on 12th day.抄録全体を表示PDF形式でダウンロード (766K) -
山本 弘明, 吉村 英敏1973 年 21 巻 10 号 p. 2237-2242
発行日: 1973/10/25
公開日: 2008/03/31
ジャーナル フリーThe present investigation was undertaken to establish the structures of two metabolites which were isolated from the feces of rats administered with 2, 4, 3', 4'-tetrachlorobiphenyl (2, 4, 3', 4'-TCB), a major component of commercial preparation of polychlorinated biphenyls. For this purpose six possible isomers of monohydroxy-2, 4, 3', 4'-TCB were synthesized by condensation reactions between appropriate diazotized dichloroanilines and dichlorophenols. Among these isomers, 5-hydroxy-and 3-hydroxy-2, 4, 3', 4'-TCB were shown to be identical with a major metabolite (M-A2), mp 155-156°, and a minor metabolite (M-A1), mp 92-98°, respectively. Further study was made to know the acute lethal dose of 2, 4, 3', 4'-TCB and its major metabolite, 5-hydroxy-2, 4, 3', 4'-TCB, by i.p. injection using male mice of CF-1 strain. The results showed that LD50 of 2, 4, 3', 4'-TCB and 5-hydroxy-2, 4, 3', 4'-TCB were 2.15 g/kg and 0.43 g/kg, respectively, suggesting that acute toxicity of 2, 4, 3', 4'-TCB might be attributable to phenolic metabolites produced in vivo.抄録全体を表示PDF形式でダウンロード (668K) -
菊池 徹, 高山 雅治, 豊田 達郎, 有本 昌弘, 丹羽 峰雄1973 年 21 巻 10 号 p. 2243-2251
発行日: 1973/10/25
公開日: 2008/03/31
ジャーナル フリーThe structures of pachysandiol-B and pachysonol, new friedelin type triterpenes isolated from the neutral fraction of Pachysandra terminalis SIEB. et ZUCC. (Buxaceae), were investigated and assigned to the formulae Ia and IIa, respectively, on the basis of chemical and spectroscopic evidences.抄録全体を表示PDF形式でダウンロード (1078K) -
新宮 徹朗, 横井 利夫, 丹羽 峰雄, 菊池 徹1973 年 21 巻 10 号 p. 2252-2256
発行日: 1973/10/25
公開日: 2008/03/31
ジャーナル フリーThe nuclear magnetic resonance spectra of triterpene acetates related to β-amyrin were examined by use of the shift reagent Eu (DPM)3 and assignments of their methyl resonances have been performed. Furthermore, the most favourable conformation of the co-ordinate complex was suggested based on the consideration of molecular models and the angle term in McConnel-Robertson equation.抄録全体を表示PDF形式でダウンロード (609K) -
酒井 秀夫, 伊藤 敬一, 関屋 実1973 年 21 巻 10 号 p. 2257-2264
発行日: 1973/10/25
公開日: 2008/03/31
ジャーナル フリーThe substitution of the dialkylamine residue of N-(dialkylaminomethyl) amides with nucleophiles leading to the formation of the amidomethyl compounds, reported in several papers by Hellmann, et al. has been shown not to occur with sulfides and cyanide under the condition of heating in methanol preferably in the presence of sodium hydroxide, whereas the substitution of the amide residue is chiefly effected. By similar manners the substitution reactions of N-(α-dialkylaminobenzyl) amides with sulfides and cyanide have been also realized.抄録全体を表示PDF形式でダウンロード (797K) -
近藤 嘉和, 竹本 常松1973 年 21 巻 10 号 p. 2265-2267
発行日: 1973/10/25
公開日: 2008/03/31
ジャーナル フリーA new diglyceride, α, β-dimontanyl glycerol (I) has been isolated from the root-barks of Morus alba L. The structure of I has been evidenced by chemical and physical methods.抄録全体を表示PDF形式でダウンロード (479K) -
湊 均, 片山 照明, 松本 誠, 片桐 謙, 松浦 真三, 砂川 則雄, 堀 賢司, 原田 稔, 竹内 三津男1973 年 21 巻 10 号 p. 2268-2277
発行日: 1973/10/25
公開日: 2008/03/31
ジャーナル フリーCytochalasin D (zygosporin A) showed strong cytotoxic effect with a unique cytopathogenic change. Further, cytochalasin D inhibited the growth of several rat tumors in a narrow chemotherapeutic index range owing to its irritating toxicity. More than 30 derivatives of zygosporin were synthesized, and structure-biology relationship was discussed for cytotoxicity and skin irritating activity. Among the derivatives, cytochalasin C has similar cytotoxicity to cytochalasin D, accompanied by a decreased lethal toxicity. It is disappointing, however, that the chemotherapeutic index of cytochalasin C is no different from that of cytochalasin D.抄録全体を表示PDF形式でダウンロード (1001K) -
栗原 弘三, 市川 泉夫1973 年 21 巻 10 号 p. 2278-2285
発行日: 1973/10/25
公開日: 2008/03/31
ジャーナル フリーThe effects of the particle-shape (which is irregular, rod-like or spherical) and the ratio of interparticle-cohesion/particle-weight on the initial fractional voidage before tapping, the rate of tapping-compaction and the final fractional voidage attained by tapping were studied. The samples were monodispersed powders with their sizes ranging from 12 to 127 μ. A good correlation was found between the initial fractional voidage and Fo/ρpdp3 except for the rod-like particles. The initial fractional voidage of the rod-like particles is much greater than that of the irregular or spherical ones, which is explained in terms of the strong mechanical resistance caused by interlocking of particles due to the high elongation of the rod-like particles. In the dense packing the structural resistance is more pronounced than in the loose packing and, moreover, in the dense packing the effect of the compacting-force must be taken into account in the calculation of the interparticle cohesion. The rate of tapping-compaction suffers from little influence of the particle-shape. The physical meanings of the correlations which have been found empirically between the angle of repose and ε0 or ΔV could be elucidated to some extent through the relations between each of them and Fo/ρpdp3.抄録全体を表示PDF形式でダウンロード (756K) -
高橋 千加子, 関田 節子, 義平 邦利, 名取 信策, 宇田川 俊一, 倉田 浩, 榎本 眞, 大坪 浩一郎, 梅田 誠, 斎藤 守1973 年 21 巻 10 号 p. 2286-2291
発行日: 1973/10/25
公開日: 2008/03/31
ジャーナル フリーFifteen strains of Phoma species were examined for their production of toxic metabolite (s). Although three of them showed the toxicity for cultured HeLa cells and mice and the metabolites were not identical with the known metabolites, attempts to isolate toxic principle (s) were abandoned due to their instability. In the course of the work cynodontin (3), 6-methylsalicylic acid, an unidentified phenolic of mp 191-193°, and a chromanone (4) were isolated. The chromanone (4) was proved to be (2R)-5-hydroxy-6-(2'-hydroxyethyl)-7-methoxy-2-methylchromanone.抄録全体を表示PDF形式でダウンロード (679K) -
ヒキノ ヒロシ, 奥山 徹, 神 久徳, 竹本 常松1973 年 21 巻 10 号 p. 2292-2302
発行日: 1973/10/25
公開日: 2008/03/31
ジャーナル フリーJapanese ferns from 20 families, representing 76 genera, 283 species, 39 varieties, and 1 form, have been subjected to screening tests by means of bioassay for the presence of phytoecdysones. A total of 170 species, 22 varieties, and 1 form have been found to show the insect moulting hormone activity. The taxonomical relationship is discussed.抄録全体を表示PDF形式でダウンロード (1113K) -
小橋 恭一, 寺島 信雄, 長谷 純一1973 年 21 巻 10 号 p. 2303-2308
発行日: 1973/10/25
公開日: 2008/03/31
ジャーナル フリーBorate was found to prevent or reverse remarkably the inhibition of urease activity by hydroxamic acids. Based on these facts, formation of hydroxamic acid-borate complex was studied spectrophotometrically. 1. All the metal ions tested except boric ion showed little protective effect against hydroxamate-inhibition of urease activity. 2. Characteristic absorption maximum of benzohydroxamic acid-borate complex was observed at 265 nm in the pH range from 8 to 11. The investigation of pH effect on the ultraviolet absorption of the complex suggests that keto form of hydroxamic acidborate complex is tautomerized to imidol-borate complex around neutral pH, which is dissociated to the imidol anion and borate in a more alkaline pH range than 11. Aluminate is assumed spectrophotometrically to form the similar complex with benzohydroxamic acid, though it did not prevent the inhibition of urease activity by hydroxamic acid. 3. Based upon these observations, we proposed new spectrophotometric methods of determination of benzohydroxamic acid, borate and aluminate.抄録全体を表示PDF形式でダウンロード (725K) -
森下 孝, 山崎 勝, 矢田 登, 鎌田 皎1973 年 21 巻 10 号 p. 2309-2322
発行日: 1973/10/25
公開日: 2008/03/31
ジャーナル フリーThe absorption of sulfonamides through the rat intestine was studies with an in situ perfusion method employing pH adjusted isotonic saline solutions. The absorption was expressed as the absorbed amounts in one hour and first-order rate constants in terms of the unionized and anionic forms of the drugs. Regression analysis following Hansch, et al. were carried out to correlate the intestinal absorption of the drugs with their physicochemical parameters. Physicochemical parameters, such as partition coefficients from chloroform, n-octyl alcohol and lecithin contained chloroform, adsorption to the rat blood, adsorption to activated charcoal, molecular weight and dissociation constant, were used. The intestinal absorption of sulfonamides was satisfactorily predicted with the use of equations of the regression analysis.抄録全体を表示PDF形式でダウンロード (1359K) -
有澤 宗久, 森田 直賢, 近藤 嘉和, 竹本 常松1973 年 21 巻 10 号 p. 2323-2328
発行日: 1973/10/25
公開日: 2008/03/31
ジャーナル フリーIrifloside (III), C23H22O12·H2O, mp 177-178°, a new isoflavone glycoside, has been isolated from the rhizoma of Iris florentina L. (Iridaceae) together with iriflophenone (II), irisolone (IV), irisflorentin (I), iristectorigenin B (V), irigenin (VI) and iridin (VII). The structure of irifloside (III) has been determined as 5, 4'-dihydroxy-3'-methoxy-6, 7-methylenedioxyisoflavone-4'-O-β-D-glucoside by chemical degradation and spectral means, and its aglycone, C17H12O7, mp 221-223°, was named iriflogenin (VIII). The structure of iriflophenone (II), C13H10O5, mp 207-208°, has been determined as 2, 4, 6, 4'-tetrahydroxybenzophenone by spectral means.抄録全体を表示PDF形式でダウンロード (640K) -
鎌滝 哲也, 北田 光一, 北川 晴雄1973 年 21 巻 10 号 p. 2329-2331
発行日: 1973/10/25
公開日: 2008/03/31
ジャーナル フリーPDF形式でダウンロード (476K) -
曾根 孝範, 広井 邦雄, 山田 俊一1973 年 21 巻 10 号 p. 2331-2335
発行日: 1973/10/25
公開日: 2008/03/31
ジャーナル フリーPDF形式でダウンロード (662K) -
竹本 常松, 奥山 徹, 神 久徳, 荒井 富雄, 河原 衛雄, 今野 長八, 鍋谷 将, 在原 重信, 曳野 靖子, ヒキノ ヒロシ1973 年 21 巻 10 号 p. 2336-2338
発行日: 1973/10/25
公開日: 2008/03/31
ジャーナル フリーPDF形式でダウンロード (488K) -
菊池 徹, 三村 鉄太郎, 伊藤 義邦, 森脇 祥寿, 根来 健一郎, 正田 芳郎, 井上 武久1973 年 21 巻 10 号 p. 2339-2341
発行日: 1973/10/25
公開日: 2008/03/31
ジャーナル フリーPDF形式でダウンロード (440K) -
小林 五郎, 富永 義則, 木崎 俊一, 曾根 正勝, 上野 精一1973 年 21 巻 10 号 p. 2344-2345
発行日: 1973/10/25
公開日: 2008/03/31
ジャーナル フリーPDF形式でダウンロード (354K) -
石井 永, 石川 勉, 関口 文男, 細谷 勝弘1973 年 21 巻 10 号 p. 2346-2348
発行日: 1973/10/25
公開日: 2008/03/31
ジャーナル フリーPDF形式でダウンロード (381K)
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