巻号一覧
13 巻, 11 号
選択された号の論文の20件中1～20を表示しています
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古川 純康, 小林 邦夫, 金井 良雄, 本庄 美喜男1965 年 13 巻 11 号 p. 1273-1278
発行日: 1965/11/25
公開日: 2008/03/31
ジャーナル フリーMethylation of 3', 5'-di-O-trityluridine (I) gave a mixture of two compounds, which was detritylated and then separated to give N3, 2'-O-dimethyluridine (V) and 2'-O-methyluridine (VI). After treatment of the above mixture with ethanolic ammonia, the reaction products were detritylated and separated to give V and 2'-O-methyl-cytidine (VII). By a similar method 3'-O-methyl nucleosides were obtained from 2', 5'-di-O-trityluridine (II). The relative rates of acidic hydrolysis of uridine, VI, and 3'-O-methyluridine have been determined and were shown to obey first order kinetics. Introduction of a methoxyl function at the 2'- or 3'-position of uridine enhances the stability of the glycosyl linkage to acid hydrolysis.抄録全体を表示PDF形式でダウンロード (705K) -
山田 秀雄, 山本 隆一1965 年 13 巻 11 号 p. 1279-1284
発行日: 1965/11/25
公開日: 2008/03/31
ジャーナル フリー1) The model of absorption of drug in micellar solution from the intestine is proposed. According to this model, the relationship between concentration of the surfactant and absorption rate constant of the drug was derived. The calculated values of the absorption rate constants from the equation were compared with the experimentally observed values.2) The determination of absorption rate constant was carried out by the perfusion of salicylamide solutions containing polysorbate-80 in various concentrations through the rat small intestine in situ. 3) The experimental results indicate that there is a quite agreement between the observed value and the calculated value.抄録全体を表示PDF形式でダウンロード (692K) -
三木 卓一, 平賀 謙太郎, 朝子 典彦1965 年 13 巻 11 号 p. 1285-1289
発行日: 1965/11/25
公開日: 2008/03/31
ジャーナル フリーA short step synthesis of estradiol was presented. 1-Vinyl-6-methoxy-1-tetralol (I) was condensed with 2-methyl-1, 3-cyclopentanedione (II)in the presence of Triton B to give dl-3-methoxy-8, 14-secoestra-1, 3, 5(10), 9-tetraene-14, 17-dione (III) which was converted by phosphorus pentoxide into the known dl-3-methoxyestra-1, 3, 5(10), 8, 14-pentaen-17-one(IV). The ketone (IV) was treated with sodium borohydride in methanol, yielding dl-3-methoxyestra-1, 3, 5(10), 8, 14-pentaen-17β-ol(V). Catalytic hydrogenation of this compound over Raney nickel was found to be stereospecific, yielding dl-3-methoxyestra-1, 3, 5, (10), 8-tetraen-17β-ol(VI). This compound was subjected to K-NH3reduction to give dl-estradiol 3-methyl ether (VII).Racemic V was resolved through its 17 l-menthoxyacetate and d-estradiol 3-methyl ether obtained by the above series of reactions was identical with the material of natural origin. dl-Equilenin 3-methyl ether was prepared from dl-3-methoxyestra-1, 3, 5(10), 8-tetraen-17β-ol (VI) by oxidation with Jones' reagent at one step.抄録全体を表示PDF形式でダウンロード (648K) -
平賀 謙太郎1965 年 13 巻 11 号 p. 1289-1294
発行日: 1965/11/25
公開日: 2008/03/31
ジャーナル フリーDuring the course of the synthesis of 18-methylestradiol 3-methyl ether, steric effect caused by the methyl group at 18-position was observed. It was found that ethylenediamine was a good solvent for the ethynylation reaction of the hindered ketone. Racemic and optically active 17β-hydroxy-13β, 17α-diethylgon-4-en-3-one were synthesized from 1-vinyl-6-methoxy-1-tetralol and 2-ethyl-1, 3-cyclopentanedion. The dextrorotatory diethylgonenone as well as the corresponding racemic diethylgonenone showed strong anabolic activities, whereas the levorotatory compound had no biological activity.抄録全体を表示PDF形式でダウンロード (719K) -
平賀 謙太郎, 朝子 典彦, 三木 卓一1965 年 13 巻 11 号 p. 1294-1299
発行日: 1965/11/25
公開日: 2008/03/31
ジャーナル フリーdl-18, 18-Dimethylestradiol 3-methyl ether (XII), dl-18, 18-dimethyl-19-nortestosterone (II) and their derivatives were synthesized starting from 1-vinyl-6-methoxy-1-tetralol (III) and 2-isopropyl-1, 3-crclopentanedione (IV). The steric effect of the 13-isopropyl group over 17-position was observed in every kind of reactions in this series. Both II and dl-17α-ethyl-18, 18-dimethyl-19-nortestosterone (XX) showed almost no anabolic and androgenic activity.抄録全体を表示PDF形式でダウンロード (752K) -
平賀 謙太郎1965 年 13 巻 11 号 p. 1300-1306
発行日: 1965/11/25
公開日: 2008/03/31
ジャーナル フリーBased on the results of physicochemical measurements, the enolic forms of 1, 3-cyclopentanediones (IV), 1, 2, 4-cyclopentanetriones (XI), semicarbazones of 1, 2, 4-cyclopentanetriones and ethyl 2, 4, 5-trioxocyclopentylglyoxylate were discussed, and the structures (IX, XII, XV, and XVI) were proposed respectively.抄録全体を表示PDF形式でダウンロード (633K) -
堀井 善一, 池田 正澄, 田村 恭光, 斎藤 清一, 小寺 啓司, 岩本 務1965 年 13 巻 11 号 p. 1307-1311
発行日: 1965/11/25
公開日: 2008/03/31
ジャーナル フリーThe leaves of Securinega suffruticosa REHD. furnished three new alkaloids, securinol A, B and C. The structures of securinol A and B were investigated.抄録全体を表示PDF形式でダウンロード (637K) -
堀井 善一, 山脇 泰彦, 田村 恭子, 斎藤 清一, 吉川 浩, 小寺 啓司1965 年 13 巻 11 号 p. 1311-1318
発行日: 1965/11/25
公開日: 2008/03/31
ジャーナル フリーDegradations of allosecurinine (III) gave the N-acetyl amino-lactone (IX), lactam-car-binol C (XIII), quinolizidine C (XVI), tetrahydroallosecurinine (XVIII) and compound (XIX). Identifications of the former three compounds (IX), (XIII) and (XVI) with the corresponding synthetic specimens provided a definite proof for the relative configuration of allose-curinine (III).抄録全体を表示PDF形式でダウンロード (948K) -
関屋 実, 尾崎 義朗1965 年 13 巻 11 号 p. 1319-1325
発行日: 1965/11/25
公開日: 2008/03/31
ジャーナル フリーFormation of 5-acetamido-substituted thiazoles was found to be readily effective on heating 2-(acylamino)thioacetamides with acetic anhydride. In additon, preparation of some starting 2-(acylamino)thioacetamides is described and 5-acetamidothiazole-4-carboxamides obtained by the thiazole formation reaction were led to some thiazolo[5, 4-d]pyrimidines.抄録全体を表示PDF形式でダウンロード (958K) -
矢島 治明, 久保 一雄, 岡田 芳男1965 年 13 巻 11 号 p. 1326-1331
発行日: 1965/11/25
公開日: 2008/03/31
ジャーナル フリーThe syntheses of three pentapeptide isomers, L-histidyl-D-phenylalanyl-D-arginyl-L-tryptophylglycine (II), D-histidyl-D-phenylalanyl-D-arginyl-L-tryptophylglycine (III) and L-histidyl-D-phenylalanyl-D-arginyl-D-tryptophylglycine (IV) were described. Nα-Ben-zyloxycarbonyl-D-phenylalanyl-NG-nitro-D-arginine served as a key intermediate for the synthesis of these isomers. Melanocyte-stimulating activities of these compounds were examined using the frog-skin from Rana pipiens. It was found that II possessed the activity identical to that of L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycine (I). The peptides (III) and (IV) were both inactive.抄録全体を表示PDF形式でダウンロード (846K) -
三橋 博, 野村 太郎1965 年 13 巻 11 号 p. 1332-1340
発行日: 1965/11/25
公開日: 2008/03/31
ジャーナル フリーThe structure of benzoylramanone (III), a new ester type aglycone from Metaplexis japonica MAKINO, has been proved by chemical conversions and spectroscopic examination of the conversion products. The structural conclusion have been confirmed by correlation with a degradation product from hecogenin.抄録全体を表示PDF形式でダウンロード (998K) -
冨田 真雄, 冨士谷 憲徳, 青柳 良明1965 年 13 巻 11 号 p. 1341-1345
発行日: 1965/11/25
公開日: 2008/03/31
ジャーナル フリーCupric oxide catalyst improved the yield in some Ullmann condensation reactions affording diaryl ether derivatives. Though it was not concluded whether cupric oxide was the ture catalytic species or not, its efficiency was proved.抄録全体を表示PDF形式でダウンロード (610K) -
村上 孝夫, 糸川 秀治, 卯月 富美子, 沢田 尚敏1965 年 13 巻 11 号 p. 1346-1352
発行日: 1965/11/25
公開日: 2008/03/31
ジャーナル フリーIt was discussed that the relations between Rf values and the structures of 50 samples of triterpenoids and related compounds on silica gel G and alumina G, using 11 kinds of solvent systems. Four konds of reagents were used for detection.抄録全体を表示PDF形式でダウンロード (641K) -
田中 光也, 利光 淑子1965 年 13 巻 11 号 p. 1353-1358
発行日: 1965/11/25
公開日: 2008/03/31
ジャーナル フリーMethyl N-(benzyloxycarbonylaminoacyl)-β-D-glucosaminides and N-(benzyloxycarbonylaminoacyl)-D-glucosaminols were prepared and the periodate oxidation of some of these compounds was studied. Saponification of N-(β-benzyl-N-benzyloxycarbonyl-α-L-aspartyl)-tri-O-acetyl-D-glucosaminide (IIId) caused a transpeptidation to give the β-aspartyl derivative (IVd) and the α-isomer (IVf) was prepared by deacetylation of N-(N-benzyloxycarbonyl-α-aspartyl)-tri-O-acetyl-D-glucosaminide (IIIf), which was obtained by the reaction of N-benzyloxycarbonyl-L-aspartic anhydride with methyl-tri-O-acetyl-β-D-glucosaminide (II).抄録全体を表示PDF形式でダウンロード (817K) -
平賀 謙太郎1965 年 13 巻 11 号 p. 1359-1361
発行日: 1965/11/25
公開日: 2008/03/31
ジャーナル フリー2-Ethyl, 2-isopropyl and 2-benzyl-1, 3-cyclopentanediones were synthesized by the known method. Diethyl 2-methyl-3-oxoadipate was cyclized to 2-methyl-1, 3-cyclopentanedione by heating with potassium tert-butoxide. 3-Methyl-1, 2, 4-cyclopentanetrione was reduced to 2-methyl-1, 3-cyclopentanedione by Clemmensen method.抄録全体を表示PDF形式でダウンロード (394K) -
Mahmoud M. El-Merzabani1965 年 13 巻 11 号 p. 1362-1363
発行日: 1965/11/25
公開日: 2008/03/31
ジャーナル フリーA simple method was described for the synthesis of 3, 3'-dimesyloxy-N-methyl[14C]-dipropylamine hydrochloride in 29% yield, together with a method for recovery of the aminoalcohol (II) from the impure dimesyloxy derivative.抄録全体を表示PDF形式でダウンロード (365K) -
桜井 欽夫 /, Mahmoud M. El-Merzabani1965 年 13 巻 11 号 p. 1363-1365
発行日: 1965/11/25
公開日: 2008/03/31
ジャーナル フリーSix new derivatives of sulfonic acid esters of aminoglycols were prepared and tested for their carcinostatic activity against Yoshida sarcoma. All the tested compounds showed strong cytomorphological effects on the tumor cells but not effective in prologation of life span of the tumor bearing animals.抄録全体を表示PDF形式でダウンロード (450K) -
荒田 義雄, 大橋 力1965 年 13 巻 11 号 p. 1365-1368
発行日: 1965/11/25
公開日: 2008/03/31
ジャーナル フリーJudging from the nuclear magnetic resonance spectra of I, IV and VI, the formula (VII) would be presented as the absolute configuration of nuphamine.抄録全体を表示PDF形式でダウンロード (413K) -
宮野 成二, 佐古 洋子1965 年 13 巻 11 号 p. 1372-1373
発行日: 1965/11/25
公開日: 2008/03/31
ジャーナル フリーPDF形式でダウンロード (343K) -
甲斐 文夫, 関 誠夫1965 年 13 巻 11 号 p. 1374-1376
発行日: 1965/11/25
公開日: 2008/03/31
ジャーナル フリーPDF形式でダウンロード (446K)
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