巻号一覧
15 巻, 11 号
選択された号の論文の33件中1～33を表示しています
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岡野 定輔, 相田 侃次, 池田 憲1967 年 15 巻 11 号 p. 1621-1625
発行日: 1967/11/25
公開日: 2008/03/31
ジャーナル フリーWith the object of obtaining information about the behavior of aminophylline in aqueous medium, the mode of interaction between theophylline (TP) and ethylenediamine (ED) in water was studied. The molar ratio of the solubilizate-solubilizer complex was confirmed to be 1 : 1 by means of refractometry as well as phase diagram study, and stability constant of the complex was determined by solubility method. The comparative study of TP and structurally related compounds suggested that the soluble complex is united in such a way that ionic bonding between ionized imino and amino groups of TP and ED, respectively, is stabilized by hydrogen bonding between 6-keto group of TP and amino group of ED.抄録全体を表示PDF形式でダウンロード (540K) -
池川 昭子, 青木 晴子, 増川 喜久弥, 金庭 延慶1967 年 15 巻 11 号 p. 1626-1632
発行日: 1967/11/25
公開日: 2008/03/31
ジャーナル フリーPacking problems of sodium borate and boric acid powders are investigated. The apparent volume per gram of the samples in loosest packing is nearly constant in the region larger than the critical size, but in the region smaller than that, it increases gradually with decrease of particle diameters. The critical diameters obtained at the loosest packing in air are equal to that obtained by measurement of angles of repose and sliding angles. The relations between porosity (εo, εc) or the apparent density (ρc, ρo) and particle diameter (D) are represented by εo-εc=A exp (-BD) ρc-ρo=ρA exp (-BD) and the following relations have also been obtained between porosity or apparent density and C/Mg for sodium borate powders. εo-εc=0.43 C/Mg ρc-ρo=0.72 C/Mg (εo-εc) or (ρc-ρo) might be adopted as the degree of cohesion.抄録全体を表示PDF形式でダウンロード (614K) -
堀井 善一, 池田 正澄, 花岡 美代次, 山内 昌茂, 田村 恭光, 斎藤 清一, 田中 雅, 小寺 啓司, 杉本 典夫1967 年 15 巻 11 号 p. 1633-1640
発行日: 1967/11/25
公開日: 2008/03/31
ジャーナル フリーA new alkaloid, securitinine, was isolated from the root barks of Securinega suffruticosa REHD. in Formosa, and the structure of this alkaloid was established as I.抄録全体を表示PDF形式でダウンロード (918K) -
堀井 善一, 栗原 拓史, 山本 重雄, 二宮 一弥1967 年 15 巻 11 号 p. 1641-1650
発行日: 1967/11/25
公開日: 2008/03/31
ジャーナル フリーPreparations of diethyl-, n-butyl-and 2-hydroxyisopropylamide derivatives of 4-methyl-2, 3, 4, 4a, 5, 6-hexahydrobenzo [f] quinoline-2-carboxylic acid (VI) were described. And the stereochemistries of diethyl 4-methyl-1-oxo-1, 2, 3, 4, 4a, 5, 6, 10b-octahydrobenzo [f] quinoline-2, 2-dicarboxylate (II) and related compounds were also discussed.抄録全体を表示PDF形式でダウンロード (1133K) -
高橋 秀次, 新井 守, 大木 英二1967 年 15 巻 11 号 p. 1651-1656
発行日: 1967/11/25
公開日: 2008/03/31
ジャーナル フリーA macrolide antibiotic produced by Streptomyces hygroscopicus var. azalomyceticus, azalomycin-B (I), which is activity against gram-positive bacteria and Trichomonas vaginalis, was investigated as a preliminary study for the structural elucidation. A molecular formula of I was tentatively established as C56H92O19. It was also found that an α, β, γ, δ-unsaturated ester function (X) existed as the chromophor part of the molecule.抄録全体を表示PDF形式でダウンロード (774K) -
高橋 秀次, 倉林 正明, 大木 英二1967 年 15 巻 11 号 p. 1657-1661
発行日: 1967/11/25
公開日: 2008/03/31
ジャーナル フリーThe sugar component of Azalomycin-B, a macrolide antibiotic produced by Streptomyces hygroscopicus var. azalomyceticus, was designated as 2-deoxy-L-fucose.抄録全体を表示PDF形式でダウンロード (613K) -
守屋 寛, 森脇 千秋, 秋元 節子, 山口 稽子, 岩垂 正矩1967 年 15 巻 11 号 p. 1662-1668
発行日: 1967/11/25
公開日: 2008/03/31
ジャーナル フリー^<131>I-labelled α-chymotrypsin was administered into the ligated intestine of adult rats, and 131I distribution was studied. Differences were found in the distribution in the kidney from the control experiment of 131I-KI administration in the same way. Furthermore, 131I-bound protein was surely observed in the serum after the intraintestinal administration of 131I-labelled α-chymotrypsin was comparatively stable in natural human intestinal and gastric juices under the addition of 0.033M Ca ion, but without Ca ion, it was rapidly degraded and lost its esterase activity with both juices. In in vitro experiment with the sac of everted intestine of rats, it was found that chymotrypsin was transferred from the mucosal to the serosal side with its esterase activity. From these experimental results, the possibility of the transfer of α-chymotrypsin across the intestine was discussed.抄録全体を表示PDF形式でダウンロード (828K) -
西尾 元宏1967 年 15 巻 11 号 p. 1669-1676
発行日: 1967/11/25
公開日: 2008/03/31
ジャーナル フリーNuclear magnetic resonance spectra were obtained for a number of sulfoxides, whose methylene protons are magnetically nonequivalent. The coupling constants between these protons depend on the electronic properties of the substituent adjacent to the coupling protons. The substituent effect on magnetic nonequivalence was also studied and it is demonstrated that the electronic properties of the substituent constitute an important factor responsible for the magnitude of magnetic nonequivalence.抄録全体を表示PDF形式でダウンロード (755K) -
今成 登志男, 田村 善蔵1967 年 15 巻 11 号 p. 1677-1681
発行日: 1967/11/25
公開日: 2008/03/31
ジャーナル フリーThe applicability of gas chromatography to the analysis of various types of glucuronides including ether-, ester-, N-and S-glucuronides was studied by converting them to acetyl, methyl and trimethylsilyl derivatives.抄録全体を表示PDF形式でダウンロード (566K) -
藤田 栄一, 藤多 哲朗, 鈴木 豊子1967 年 15 巻 11 号 p. 1682-1686
発行日: 1967/11/25
公開日: 2008/03/31
ジャーナル フリーβ-Sitosterol, noreugenin (I), palmitic acid, and naucleoside (VII), a new triterpene glycoside, have been isolated from Nauclea orientalis L. The direct isolation of 2-methyl-5, 7-dihydroxychromone (noreugenin)(I) from natural source has never been published, although it has been synthesized and also derived from eugenin (II) by demethylation. Upon acidic hydrolysis, naucleoside gave quinovaic acid (III) as the aglycon, together with D-xylose and L-rhamnose as the sugar moiety. The order of linkage is shown to be represented by D-xylose-L-rhamnose-(C-3)-quinovaic acid (VII).抄録全体を表示PDF形式でダウンロード (724K) -
奥田 拓男, 吉田 隆志1967 年 15 巻 11 号 p. 1687-1696
発行日: 1967/11/25
公開日: 2008/03/31
ジャーナル フリーThe structure (III) is assigned to coriamyrtin on the basis of the formation of apocoriamyrtin (IV), dihydrocoriamyrtinpentaol (X), isohydrocoriamyrtin (XII), and other derivatives, and also of the spectral evidences.抄録全体を表示PDF形式でダウンロード (1183K) -
奥田 拓男, 吉田 隆志1967 年 15 巻 11 号 p. 1697-1704
発行日: 1967/11/25
公開日: 2008/03/31
ジャーナル フリーDihydrocoriamyrtin and α-bromocoriamyrtin were reduced with lithium aluminum hydride to afford acetals, (IV) and (V), respectively. The formation of these derivatives coupled with other evidences indicates the relative configurations of coriamyrtin to be represented by (Ia). The product of the lead tetraacetate oxidation of coriamyrtin was found to be an acetoxy-oxide (XVII) of which the correlation with the product (XVIII) of the performic acid oxidation of coriamyrtin, and also with α-bromocoriamyrtin were established. Among the two structures for dihydrocoriamyrtinpentaol, (XIb) was shown to be preferable. The problems concerning the stereo-structure of isohydrocoriamyrtin (VI), the aromatization of coriamyrtin to (XI), and some other derivatives were also investigated.抄録全体を表示PDF形式でダウンロード (981K) -
掛見 喜一郎, 有田 隆一, 堀 了平, 小西 良士1967 年 15 巻 11 号 p. 1705-1712
発行日: 1967/11/25
公開日: 2008/03/31
ジャーナル フリーThe partition coefficients, which are known to be an influencing factor in physiological dispositions of drugs, were investigated systematically with three series of barbituric acid derivatives. From the results obtained, the concentration dependence of partitioning, and specific association of molecules in both aqueous and solvent phase were not observed. The latter was supported also by the computed degree of association obtained from the diffusion data. A logarithmic relationship between partition coefficients to two different organic solvents was found to exist, and this relationship provides a useful method or information to elucidate the characterizations of partitioning mechanism and their relation to the absorption phenomena. In respect to the effect of chemical structure on partition equilibrium, it was confirmed with all derivatives and solvent systems that the partition coefficients were prediced from the two parameters of the substituent at 5-position of barbituric acid ring, namely, the mass of the substituent in number of carbon atoms, and Taft's polar constant using the equation related to Hammett's rule.抄録全体を表示PDF形式でダウンロード (714K) -
木村 道也, 藤間 貞彦, 吉沢 逸雄1967 年 15 巻 11 号 p. 1713-1719
発行日: 1967/11/25
公開日: 2008/03/31
ジャーナル フリーConvallagenin-B (III) from the flowers of Convallaria keisukei MIQ., Japanese lily of the valey, has been elucidated as 25L, 5β-spirostan-1β, 3β, 4β, 5β-tetrol, that represents the first instance of the 25L-tetrahydroxy steroidsapogenin.抄録全体を表示PDF形式でダウンロード (873K) -
渡辺 和夫, 大島 幸子, 福田 英臣1967 年 15 巻 11 号 p. 1720-1725
発行日: 1967/11/25
公開日: 2008/03/31
ジャーナル フリー1. Relationship between urease activity in gastric mucosa and ammonia content of gastric juice was examined in 3 species of laboratory animals. The close relation was confirmed between them. 2. Urease inhibitory effects of some agents were compared in vivo and their influence on gastric ammonia production was examined in mice. Benzohydroxamic acid, a specific inhibitor of urease, distinctively reduced gastric ammonia production. 3. By intravenous injection of urea, ammonia content of gastric juice was markedly increased. 4. Repeated administrations of urea activated gastric urease activity and gastric ammonia production. 5. Repeated administrations of urea reduced the incidence of gastric errosion which was induced by reserpine in mice. 6. All these results may suggest the important role of gastric urease in defensive mechanism of gastric mucosa.抄録全体を表示PDF形式でダウンロード (656K) -
高橋 秀次, 大木 英二1967 年 15 巻 11 号 p. 1726-1732
発行日: 1967/11/25
公開日: 2008/03/31
ジャーナル フリーAlkaline degradation of azalomycin-B, a macrolide antibiotic produced by Streptomyces hygroscopicus var. azalomyceticus, afforded oct-4-en-3-one (II), an unsaturated keto-alcohol (X), and 2, 4-dimethylphenylacetic acid (VIII), accompanied with lower-graded degradation products. Based on elucidated structures of these products, a partial structure of (XIV) was proposed for this antibtotic.抄録全体を表示PDF形式でダウンロード (876K) -
大草 源三, 長田 瑞江, 神谷 庄造1967 年 15 巻 11 号 p. 1733-1737
発行日: 1967/11/25
公開日: 2008/03/31
ジャーナル フリーThe Mannich reaction of 6-chloro-and 6-methyl-3-pyridazinol 1-oxide using morpholine or piperidine gave 6-chloro-and 6-methyl-4-alkylaminomethyl-3-pyridazinol 1-oxide. Treatment of 3-pyridazinol 1-oxide with excess amounts of the reagents gave 4, 6-di (morpholinomethyl)-3-pyridazinol 1-oxide in 71% yield. These Mannich bases were catalytically hydrogenated to give the corresponding 4-alkylaminomethyl-3(2H)-pyridazinones almost quantitatively.抄録全体を表示PDF形式でダウンロード (627K) -
金岡 祐一, 町田 実, 伴 義雄, 関根 隆光1967 年 15 巻 11 号 p. 1738-1743
発行日: 1967/11/25
公開日: 2008/03/31
ジャーナル フリーA novel approach to studies of structure and function of proteins utilizing fluorescencelabeled specific reagent is proposed. N-[p-(2-Benzoxazolyl) phenyl] maleimide (IIIa) and N-[p-(2-benzthiazolyl) phenyl] maleimide (IIIb) were synthesized as sulfhydryl reagents of this type and the addition reaction with cysteine ester was investigated. Cyclization of maleamic acids with PPA is demonstrated to be a good method for synthesis of N-substituted maleimides.抄録全体を表示PDF形式でダウンロード (781K) -
高木 敬次郎, 高柳 一成, 石 竹根1967 年 15 巻 11 号 p. 1744-1748
発行日: 1967/11/25
公開日: 2008/03/31
ジャーナル フリーThe mode of action of pilocarpine, arecoline and 1-ascorbic acid was studied on the isolated ileum of the guinea pig. It was given as a conclusion that pilocarpine and arecoline accelerated the acetylcholine liberation to contract the ileum and that 1-ascorbic acid depressed the acetylcholine liberation from the guinea pig ileum.抄録全体を表示PDF形式でダウンロード (861K) -
水野 初彦, 寺島 孜郎, 阿知波 一雄, 山田 俊一1967 年 15 巻 11 号 p. 1749-1756
発行日: 1967/11/25
公開日: 2008/03/31
ジャーナル フリーThe absolute configuration of (+)-α-methylphenylglycine was proved to be S series by the chemical correlation with R (-)-isovaline. Chemical scheme employed was shown in Chart 1. Moreover, in the course of the chemical correlation, the absolute configuration of (+)-1-methyl-1-phenylpropylamine was also proved to be R series. Preliminary experiments using racemic compounds were also described.抄録全体を表示PDF形式でダウンロード (978K) -
柴田 承二, 森下 頴策, 有馬 康男1967 年 15 巻 11 号 p. 1757-1764
発行日: 1967/11/25
公開日: 2008/03/31
ジャーナル フリーRubrofusarin, a metabolic product of Fusarium culmorum Sacc. and its methyl ethers were synthesized by the Claisen condensation of 2-acetylnaphthalene derivatives (XIII, XV and XVIII), which were prepared starting from α-resorcylic acid. The structures of rubrofusarin monomethyl ether A and nor-rubrofusarin diacetate were established spectrometrically and synthetically.抄録全体を表示PDF形式でダウンロード (963K) -
森下 頴策, 柴田 承二1967 年 15 巻 11 号 p. 1765-1771
発行日: 1967/11/25
公開日: 2008/03/31
ジャーナル フリーOctamethyl ether of product A which was derived from ustilaginoidin A by alkaline degradation was synthesized by the Ullmann condensation of dimethyl ether of 5-bromo-6, 8-dimethyl-1, 3-naphthalenediol (XXI). Starting from 3, 5-dimethoxyphenylacetic acid (IX), the 2-bromo derivative (VII) was prepared which was C-acetylated to afford XX, and then cyclized to form a bromonaphthalene derivative (XXI), whose methyl ether is XXII. The position of C-C linkage connecting two monomeric moieties of ustilaginoidins has unequivocally been established. Rearrangement of bromine atom during the process of methylation of bromohydroxynaphthalenes and cyclization forming the naphthalene nucleus were also discussed.抄録全体を表示PDF形式でダウンロード (842K) -
森下 頴策, 柴田 承二1967 年 15 巻 11 号 p. 1772-1775
発行日: 1967/11/25
公開日: 2008/03/31
ジャーナル フリーRacemic ustilaginoidin A was synthesized by the oxidative coupling of nor-rubrofusarin dimethyl ether C (II) and rubrofusarin monomethyl ether A (III) using ferric chloride in dioxane as the reagent.抄録全体を表示PDF形式でダウンロード (545K) -
高村 則夫, 寺島 孜郎, 阿知波 一雄, 山田 俊一1967 年 15 巻 11 号 p. 1776-1784
発行日: 1967/11/25
公開日: 2008/03/31
ジャーナル フリーThe absolute configuration of (+)-α-methylserine ((+)-IX) obtained from natural source, has been elucidated to be S-configuration by the chemical correlation with (+)-isovaline ((+)-VII), at the same time the absolute configuration of (+)-2-amino-2-methyl-3-butenoic acid ((+)-XI) has also been proved to be S-series. Chemical schemes employed were shown in Charts 1 and 2. Optically active hydantoins (V and VIII) used in the correlation were prepared by the direct resolution of racemic hydantoins with brucine. Preliminary examinations using racemic compounds were also reported.抄録全体を表示PDF形式でダウンロード (1163K) -
田原 昭, 平尾 健一, 浜崎 泰彦1967 年 15 巻 11 号 p. 1785-1790
発行日: 1967/11/25
公開日: 2008/03/31
ジャーナル フリーFrom l-abietic acid, a basic skeleton compound (XX) having same absolute configuration and characterized nitrogen bridge of diterpene alkaloid, was accomplished to synthesize.抄録全体を表示PDF形式でダウンロード (830K) -
畑 俊一, 水野 光司, 富岡 穂一1967 年 15 巻 11 号 p. 1791-1795
発行日: 1967/11/25
公開日: 2008/03/31
ジャーナル フリーAmong nine pharmaceutical preparations, the values of parameters λh.o. and λl.e. representing the energy levels of the highest occupied molecular orbital and the lowest empty molecular orbital were obtained by a molecular orbital method, simple LCAO MO method of π-electrons. On the basis of these calculations, it was found that eight electron donors used formed the molecular complex with menadione in aqueous media. The free energy changes in the complex formation tend to be increased by the addition of better eletron donors. As a result, it was suggested that the driving force of the complex formation would be due to charge transfer force.抄録全体を表示PDF形式でダウンロード (566K) -
畑 俊一, 水野 光司, 富岡 穂一1967 年 15 巻 11 号 p. 1796-1799
発行日: 1967/11/25
公開日: 2008/03/31
ジャーナル フリーThe photodecomposition of menadione in aqueous electron donor solutions were studied. As a result of these measurements, it was found that menadione was stabilized in the presence of various electron donors. Therefore, the relationships between the rate of stabilization and the various constants related to the complex formation which is due to the mutual reaction of electrons between menadione and various electron donors seemed to play an important role in stabilization of menadione.抄録全体を表示PDF形式でダウンロード (400K) -
日野 亨, 中川 昌子, 赤星 三弥1967 年 15 巻 11 号 p. 1800-1803
発行日: 1967/11/25
公開日: 2008/03/31
ジャーナル フリーPDF形式でダウンロード (577K) -
岩重 忠博, 佐伯 博道1967 年 15 巻 11 号 p. 1803-1806
発行日: 1967/11/25
公開日: 2008/03/31
ジャーナル フリーPDF形式でダウンロード (588K) -
松本 純一, 南 新作1967 年 15 巻 11 号 p. 1806-1808
発行日: 1967/11/25
公開日: 2008/03/31
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井深 俊郎, 北野 正彦1967 年 15 巻 11 号 p. 1809-1810
発行日: 1967/11/25
公開日: 2008/03/31
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岡野 定輔, 上釜 兼人1967 年 15 巻 11 号 p. 1812-1815
発行日: 1967/11/25
公開日: 2008/03/31
ジャーナル フリーPDF形式でダウンロード (569K) -
村上 孝夫, 三上 芳子, 糸川 秀治1967 年 15 巻 11 号 p. 1817-1818
発行日: 1967/11/25
公開日: 2008/03/31
ジャーナル フリーPDF形式でダウンロード (344K)
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