巻号一覧
8 巻, 5 号
選択された号の論文の20件中1～20を表示しています
- |<
- <
- 1
- >
- >|
-
太田 達男, 森 陽, 野田 千秋, 青木 透1960 年 8 巻 5 号 p. 377-379
発行日: 1960/05/25
公開日: 2008/03/31
ジャーナル フリーThe leaves of Ruta graveolens L. contained skimmianine and kokusaginine. The latter was hydrogenated to give 2, 3-dihydrokokusaginine, which was identical with 4, 6, 7-trimethoxy-2, 3-dihydrofuro [2, 3-b] quinoline prepared from 4, 6, 7-trimethoxy-3- (2-ethoxyethyl) carbostyril by cyclization with polyphosphoric acid.抄録全体を表示PDF形式でダウンロード (441K) -
石川 文義, 野村 哲士, 上田 亨, 池原 森男, 水野 義久1960 年 8 巻 5 号 p. 380-384
発行日: 1960/05/25
公開日: 2008/03/31
ジャーナル フリーAcetolysis of 2', 3', 5'-tri-O-benzoylguanosine with glacial acetic acid, acetic anhydride, and sulfuric acid gave rise to 1-O-acetyl-2, 3, 5-tri-O-benzoyl-β-D-ribofuranose in a fairly good yield (overall yield from guanosine was 50%). This method will afford a most convenient procedure for preparing 1-O-acetyl-2, 3, 5-tri-O-benzoyl-β-D-ribofuranose which is a key intermediate in the synthesis of ribonucleosides and ribonucleotides. The direct acetolysis is one of the rare cases in which N-glycosides are easily acetolyzed without cleavage of the furanoside ring. Some observations on hydrolysis and acetolysis of 2', 3', 5'-tri-O-benzoylguanosine were also described.抄録全体を表示PDF形式でダウンロード (632K) -
内山 充, 浮田 忠之進1960 年 8 巻 5 号 p. 384-388
発行日: 1960/05/25
公開日: 2008/03/31
ジャーナル フリーAluminum citrate, aluminum tricarballylate, and aluminum lactate were prepared to test their activity for insolubilization of the phosphate, both in vitro and in vivo, and for facilitating the excretion of administered radioactive strontium, in comparison with those of dihydroxyaluminum aminoacetate, which was previously reported as an effective agent for elimination of strontium. According to the results of experiments in vitro, aluminum tricarballylate and aluminum lactate have a stronger tendency to make phosphate insoluble, but aluminum citrate has almost no activity. In the case of experiment in vivo, on the contrary, aluminum citrate showed a considerable inhibition of gastrointestinal absorption of phosphate, and moreover, it showed no untoward effect on the growth of animals, while the other two salts seem to reduce their appetite. The effect of aluminum citrate on the elimination of strontium is shown in Tables I and II. By aluminum citrate treatment, 60% of administered 90Sr was excreted in 24 hours and 70% in 6 days, compared with respective 35% and 45% in control animals.抄録全体を表示PDF形式でダウンロード (637K) -
吉田 茂1960 年 8 巻 5 号 p. 389-394
発行日: 1960/05/25
公開日: 2008/03/31
ジャーナル フリーInfrared absorptions of benzoic acid, its esters and chloride, and their para-substituted derivatives in the region of 900∼650 cm-1 were examined. It was revealed that an extra band, similar in nature to the CH deformation vibration, was present in these compounds and considerations were made on the origin of the extra band. Clarification of this extra band enabled clarification of CH deformation band.抄録全体を表示PDF形式でダウンロード (625K) -
秋谷 七郎, 星野 乙松1960 年 8 巻 5 号 p. 395-398
発行日: 1960/05/25
公開日: 2008/03/31
ジャーナル フリーThe fraction G previously isolated from Micrococcus lysodeikticus mainly consists of a muco-complex. This fraction was further purified by both electrodialysis and zone electrophoresis to separate a small amount of impurities and to obtain a single muco-complex, GIIs. The latter gave a single spot which migrated towards the anode in paper electrophoresis. The homogeneity of GIIs was further investigated by Tiselius electrophoresis and ultracentrifugation. Several measurements of physicochemical properties of GIIs, viscosity, molecular weight, osmotic pressure, and electrometric titration, were carried out. From these results, the muco-complex, GIIs, was established to be a mucopolysaccharidelike substance having a molecular weight of nearly 100, 000.抄録全体を表示PDF形式でダウンロード (548K) -
秋谷 七郎, 星野 乙松1960 年 8 巻 5 号 p. 399-404
発行日: 1960/05/25
公開日: 2008/03/31
ジャーナル フリーThe hydrolysate of muco-complex fraction (GII), isolated from Micrococcus lysodeikticus, was submitted to combined paper electrophoresis and paper chromatography, and was found to contain glucose, glucosamine, alanine, glycine, glutamic acid, lysine, and muramic acid. The last one was identified with the authentic specimen of muramic acid. The nature of the primary amino group of its peptide parts was investigated by dinitrophenylation of the muco-complex. Further, several components of the complex were quantitatively analysed.抄録全体を表示PDF形式でダウンロード (664K) -
星野 乙松1960 年 8 巻 5 号 p. 405-410
発行日: 1960/05/25
公開日: 2008/03/31
ジャーナル フリーA muco-complex (fraction GII) obtained from Micrococcus lysodeikticus in a preparative scale was hydrolyzed with lysozyme and the hydrolysate was fractionated into several components. From one of the fractions, a disaccharide consisting of acetylglucosamine and acetylmuramic acid was isolated. Further, a sequence of peptide linkage, -Lys-Ala- (Ala-Gly), in the muco-complex was established.抄録全体を表示PDF形式でダウンロード (670K) -
星野 乙松1960 年 8 巻 5 号 p. 411-416
発行日: 1960/05/25
公開日: 2008/03/31
ジャーナル フリーA purified lysozyme-hydrolysis product of muco-complex obtained from M.lysodeikticus was further investigated by hypoiodite and periodate oxidations as well as by electrometric titration to elucidate the structure of O-(N-acetylmuramic acid)-(1→4)-N-acetylglucosamine. The enzymatic specificity of lysozyme for a proposed structure of the muco-complex was discussed.抄録全体を表示PDF形式でダウンロード (686K) -
広瀬 良男1960 年 8 巻 5 号 p. 417-426
発行日: 1960/05/25
公開日: 2008/03/31
ジャーナル フリーSyntheses of damnacanthal, damnacanthol, norjuzunal and norjuzunol, the coloring matters of Damnacanthus spp. were described. The structures of juzunal and juzunol were synthetically established respectively as 2-formyl-and 2-hydroxymethyl-1-methoxy-3, 5-dihydroxyanthraquinone. These pigments are the first example of 1, 3, 5-trihydroxyanthraquinones occurring in nature.抄録全体を表示PDF形式でダウンロード (1194K) -
佐藤 義信, 岩重 忠博, 宮寺 哲男1960 年 8 巻 5 号 p. 427-435
発行日: 1960/05/25
公開日: 2008/03/31
ジャーナル フリーNew type 2, 3-disubstituted pyridine lactones were prepared from 2-methylnicotinic acid. The lactones, 2-hydroxymethylnicotinic acid lactone and 2-hydroxymethylpyridine-3-acetic acid lactone, were reacted with various amines to form the corresponding lactams, and the lactams were reduced with lithium aluminium hydride, yielding pyrrolopyridine and 1, 7-naphthyridine derivatives which possessed a fair degree of hypotensive action.抄録全体を表示PDF形式でダウンロード (968K) -
浮田 忠之進, 入江 昌親1960 年 8 巻 5 号 p. 436-440
発行日: 1960/05/25
公開日: 2008/03/31
ジャーナル フリーFor the purpose of isolation and quantitative estimation of the hydrolysis products of FAD, ion exchange column chromatography was used. The hydrolysates were fractionated stepwise from Dowex-1 (Cl-) with two systems of combined solvents : (1) Water, 0.002N hydrochloric acid, and 0.01N hydrochloric acid+0.04N ammonium chloride, and (2) 0.1N ammonium chloride and 0.1N ammonium chloride+0.01N hydrochloric acid. The former solvent system could effectively separate FR, AMP, FMP with FAD, and cyFMP, and the latter AMP, FMP with cyFMP, and FAD. The combined use of these two solvent systems was shown to effect clear-cut separation of the flavin nucleotides and adenine nucleotide contained in the hydrolysate of FAD.抄録全体を表示PDF形式でダウンロード (577K) -
伊藤 信夫1960 年 8 巻 5 号 p. 441-444
発行日: 1960/05/25
公開日: 2008/03/31
ジャーナル フリーSynthesis of 1-acetonyl-6, 7-dimethoxy-3, 4-dihydroisoquinoline (IV) was described. On treatment with boiling phosphoryl chloride this underwent a smooth prototropic change to form isoxazole derivative (II) in almost theoretical yield, which had been described previously. Some chemical evidence in support of the structure of (II) was also provided.抄録全体を表示PDF形式でダウンロード (587K) -
石舘 守三, 桜井 欽夫, 今村 博, 森脇 絢子1960 年 8 巻 5 号 p. 444-448
発行日: 1960/05/25
公開日: 2008/03/31
ジャーナル フリーMore than 200 derivatives of 2-chloroethylamine were tested as to their anti-tumor effect on the in vitro-cultured Yoshida sarcoma cells. The results were discussed, especially in connection with conditions of activation of N-methyl-bis(2-chloroethyl)amine N-oxide by the tumor cells.抄録全体を表示PDF形式でダウンロード (566K) -
今村 博1960 年 8 巻 5 号 p. 449-454
発行日: 1960/05/25
公開日: 2008/03/31
ジャーナル フリーReductive activation of the N-oxide derivatives of 2-chloroethylamine by living cells was discussed in detail and it was found that this experimental method was useful for finding a suitable means of masking of anti-tumor agents with latent activity.抄録全体を表示PDF形式でダウンロード (575K) -
上田 亨1960 年 8 巻 5 号 p. 455-458
発行日: 1960/05/25
公開日: 2008/03/31
ジャーナル フリーThe syntheses of 5-substituted uridines and their 5'-phosphates were described. 5-Bromo-2', 3'-isopropylideneuridine was phosphorylated with phosphoryl chloride and from the mixture of 5-Bromo-UMP, -UDP, and -UTP obtained, 5-Bromo-UMP was isolated by ion exchange chromatography. Phosphorylation of 5-bromo-2', 3'-isopropylideneuridine with polyphosphoric acid afforded 5-Bromo-UMP in a good yield. 5-Hydroxyuridine and its 5'-phosphate were synthesized by the addition of bromine to uridine or UMP and successive treatment with pyridine. 5-Morpholinouridine and its isopropylidene derivative were obtained from corresponding 5-bromo derivatives and morpholine, and 5-Morpholino-UMP was obtained by phosphorylation of 5-morpholino-2', 3'-isopropylideneuridine with polyphos phoric acid.抄録全体を表示PDF形式でダウンロード (553K) -
上田 亨1960 年 8 巻 5 号 p. 459-463
発行日: 1960/05/25
公開日: 2008/03/31
ジャーナル フリーβ-D-Glucose 1-phosphoramidate was synthesized by the reaction of silver benzyl phosphoramidate and acetobromoglucose, and successive hydrogenation and deacetylation. The structure of (VII) was confirmed by acid hydrolysis and optical rotation. The amidate had no ability to form pyrophosphate by phosphorolysis with another phosphate, as the other phosphoramidates do, but afforded the β-D-glucose 1, 2-cyclic phosphate, due to the specific configuration which was favorable to intramolecular cyclization. Some discussion was made about this cyclization.抄録全体を表示PDF形式でダウンロード (578K) -
上田 亨1960 年 8 巻 5 号 p. 464-468
発行日: 1960/05/25
公開日: 2008/03/31
ジャーナル フリーSyntheses of UDP-β-glucose and 5-Bromo-UDPG was attempted to investigate the stereospecificity of coenzyme UDPG. UMP-amidate and monobrucinium β-D-glucose 1-phosphate were reacted in pyridine, and UDP-β-glucose was obtained as its lithium salt by the aid of ion exchange chromatography. The structure of (VII) thus obtained was ascertained by acid hydrolysis. 5-Bromo-UMP was converted to the phosphoramidate and reacted with α-D-glucose 1-phosphate. 5-Bromo-UDPG was detected on paper chromatogram and ion exchange chromatogram, but the yield was low and 5-Bromo-UMP and another by-product were detected.抄録全体を表示PDF形式でダウンロード (590K) -
武田 健一, 米野 太一郎1960 年 8 巻 5 号 p. 468-474
発行日: 1960/05/25
公開日: 2008/03/31
ジャーナル フリーWhen steroidal 11α, 12α-, 11β, 12β-, and 9β, 11β-epoxides were each treated with thiocyanic acid, the corresponding thiocyanatohydrins were obtained. The thiocyanato and hydroxyl groups of these ring-fission products were assumed to be trans and diaxial to each other by Barton's generalization, and from infrared and ultraviolet data. This was also confirmed by chemical methods.抄録全体を表示PDF形式でダウンロード (810K) -
乙益 寛隆, 吉田 桂1960 年 8 巻 5 号 p. 475-478
発行日: 1960/05/25
公開日: 2008/03/31
ジャーナル フリー2-Hydroxyquinoxaline was nitrated with potassium nitrate in conc. sulfuric acid and formed 2-hydroxy-6-nitroquinoxaline, m.p. 306°, in 77% yield. This was treated with dimethyl sulfate and 1-methyl-2-oxo-6-nitro-1, 2-dihydroquinoxaline, m.p. 213°, was obtained, which was also prepared by the condensation of 1-methylamino-2-amino-4-nitrobenzene with butyl glyoxylate.抄録全体を表示PDF形式でダウンロード (503K) -
海尾 澄則, 西辻 和馬1960 年 8 巻 5 号 p. 479-482
発行日: 1960/05/25
公開日: 2008/03/31
ジャーナル フリーIn the synthesis of 17β-hydroxyandrostan-3-one from 3β-acetoxy-5-androsten-17-one, carbonyl group at 17-position is reduced to 17β-hydroxyl almost quantitatively by means of sodium borohydride without accompanying saponification of 3-ester. By catalytic hydrogenation over Raney nickel under high pressure and heating, double bond at 5-6 position of the steroidal B-ring is saturated and the trans-form is produced. In this case, aromatic ring at 17-ester is first reduced, followed by the double bond at 5-position. 3-Hydroxyl is oxidized to 3-keto group in a good yield on heating with activated alumina and cyclohexanone in nonpolar solvent. Finally, 17-ester is saponified quantitatively to 17β-hydroxyandrostan-3-one.抄録全体を表示PDF形式でダウンロード (533K)
- |<
- <
- 1
- >
- >|