巻号一覧
9 巻, 11 号
選択された号の論文の16件中1～16を表示しています
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平井 章一1961 年 9 巻 11 号 p. 837-845
発行日: 1961/11/25
公開日: 2008/03/31
ジャーナル フリーCyanation of cholest-4-en-3-one (I) was attempted with CN-Mg-I, Li[Al(CN)4], H[Al(tert-BuO)3CN], and H[Al(iso-PrO)8CN] respectively to give the cyano ketone compounds, but in the case of H[Al(iso-PrO)3CN], 1, 3-cyanohydrins were obtained. The reduction of epimeric 3-oxo-cholestane-5-carbonitrile with aluminum isopropoxide and with sodium borohydride afforded the four cyanohydrins which were designated as the formulae (VIII), (VII), (XII), and (XIII).抄録全体を表示PDF形式でダウンロード (1186K) -
永田 亘, 平井 章一, 青木 務, 武田 健一1961 年 9 巻 11 号 p. 845-854
発行日: 1961/11/25
公開日: 2008/03/31
ジャーナル フリー3α-Alkoxy-3β-amino-5β-cholestan-5-carbonsaure-γ-laktam, (IV oder VI), wurde einer alkalischen Degradation in Athylenglykol unterworfen und durch die nachfolgenden Umsetzungen des rohen Produktes wurde gezeigt, daβ dabei je nach der Konzentration von Alkali, 3α-Hydroxy-carbonsaure (XIV) oder 3-Oxo-carbonsaure (XII) zum groβten Teil entstanden ist, wenn auch in nicht genugender Ausbeute. Es wurde ferner gezeigt, daβ diese Degradation nach der Art der sogenannten "1, 4-Eliminierung unter Fragmentierung" verlief.抄録全体を表示PDF形式でダウンロード (1260K) -
平井 章一1961 年 9 巻 11 号 p. 854-865
発行日: 1961/11/25
公開日: 2008/03/31
ジャーナル フリーVon 3-Oxo-5α- sowie -5β-cholestan-5-carbonsauremethylester (II) bzw. (XXI) ausgehend wurde nach einer Reihe von Reaktionen 5-Methyl-5α- sowie -5β-cholestan-3-on (VIII) bzw. (XXVI) via 3-Oxo-5α- sowie -5β-cholestan-5-carbonal-3-athylenketal (VI) bzw. (XXIV) erstmalig auf deutlichem Wege dargestellt, wenn auch die Verbindungen der 5α-Reihe z. B. (VIII) und (VI) auf anderem Wege, namlich durch Reduktion von 3-Oxo-5α-cholestan-5-carbonitrilathylenketal (IX) mit Lithiumaluminiumhydrid und nachfolgende Operationen vorteilhafter darstellbar sind. Auβerdem wurden das epimere 5-Hydroxymethyl-5α- sowie -5β-cholestan-3-on (V) bzw. (XXX), 3β-Methyl-(5→3) γ- sowie 3α-Methyl-(5→3) γ-lakton (XIV) bzw. (XXXI) synthetisch hergestellt.抄録全体を表示PDF形式でダウンロード (1467K) -
関口 慶二, 小尾 陞1961 年 9 巻 11 号 p. 866-872
発行日: 1961/11/25
公開日: 2008/03/31
ジャーナル フリー1) Sulfathiazole forms eutectic mixtures with urea, l-ascorbic acid, acetamide, nicotinic acid, nicotinamide, or succinimide. It was observed that a eutectic mixture of sulfathiazole and urea produces a microcrystalline suspension of sulfathiazole in water. 2) Sulfathiazole in a eutectic mixture with urea shows higher absorption and excretion after oral administration than ordinary sulfathiazole. 3) Since urea does not possess solubilizing action on sulfathiazole and also it does not enhance absorption of the drug physiologically, the accelerated absorption or excretion must be attributed to the physical state of sulfathiazole in its eutectic mixture with easily soluble compound, such as urea. 4) It is assumed that this new form of preparation will give a means of adjusting therapeutic effect of medical compounds.抄録全体を表示PDF形式でダウンロード (698K) -
Synthesis of Potential Anticancer Agents. VII. 6-Nitro- and 6-Amino-s-triazolo [2, 3-α] pyrimidines.牧角 徳夫1961 年 9 巻 11 号 p. 873-877
発行日: 1961/11/25
公開日: 2008/03/31
ジャーナル フリーBy nitration of s-triazolo [2, 3-α] pyrimidine derivatives, four kinds of 6-nitro derivatives (Va, VIa, VIIa, and VIIIa) were obtained. These nitro compounds were converted to the corresponding 6-amino derivatives by catalytic reaction and the nature of the amino group at 6-position was examined. 2-Acetamido-1, 3-dicarbonyl compounds were condensed with 5-amino-s-triazole (IX) into 6-acetamido-s-triazolo [2, 3-α] pyrimidines (VIc, VIIc, and VIIIc), which were converted into the corresponding 6-amino derivatives by hydrolysis.抄録全体を表示PDF形式でダウンロード (634K) -
牧角 徳夫1961 年 9 巻 11 号 p. 878-882
発行日: 1961/11/25
公開日: 2008/03/31
ジャーナル フリーSeveral 6-phenylazo-s-triazolo [2, 3-α] pyrimidine derivatives were synthesized by either of the following two methods : 1) Benzenediazonium salt was coupled with s-triazolo [2, 3-α] pyrimidine derivatives at 6-position, by which the effect of 5- and 7-positions in s-triazolo [2, 3-α] pyrimidine was clarified. 2) 2-Phenylazo-1, 3-dicarbonyl compounds were condensed with 5-amino-s-triazole (IX).抄録全体を表示PDF形式でダウンロード (613K) -
牧角 徳夫1961 年 9 巻 11 号 p. 883-889
発行日: 1961/11/25
公開日: 2008/03/31
ジャーナル フリーVarious kinds of s-triazolo [2, 3-α] pyrimidine derivatives containing methyl group at 2-, 5-, and 7-positions were synthesized and the condensation of these compound with benzaldehyde was investigated. Five kinds of monostyryl derivatives and two kinds of distyryl derivatives were obtained. The structure of these styryl derivatives was confirmed by chemical methods and ultraviolet spectral measurement, and it was clarified that the methyl groups at 5- and 7-positions are active while that at 2-position was not active.抄録全体を表示PDF形式でダウンロード (739K) -
菅沢 勉1961 年 9 巻 11 号 p. 889-897
発行日: 1961/11/25
公開日: 2008/03/31
ジャーナル フリーDurch Selen-Dehydrierung des Isodesoxosongorin-Hydrochlorids (II) lieβen sich 1, 9-Dimethyl-7-athyl- und 1, 3, 9-Trimethyl-7-isopropylphenanthren isolieren. Aus diesem Grund wurde eine Bindung von 17-9 anstatt 17-10 in dem Songorin-Skelett (I) vorgeschlagen.抄録全体を表示PDF形式でダウンロード (975K) -
菅沢 勉1961 年 9 巻 11 号 p. 897-907
発行日: 1961/11/25
公開日: 2008/03/31
ジャーナル フリーEs wurde vorgeschlagen, daβ die OH-Gruppierung am A-Ring des Songorin-Skeletts nicht am C-3, sondern am C-4 steht.抄録全体を表示PDF形式でダウンロード (1294K) -
高田 純1961 年 9 巻 11 号 p. 908-914
発行日: 1961/11/25
公開日: 2008/03/31
ジャーナル フリーEight compounds of 1-(p-alkylphenyl)-1-phenyl-3-(1-piperidyl)-1-propanol series, seven compounds of 1-(p-alkylphenyl)-1-phenyl-3-dimethylamino-1-propanol series, five compounds of 3-(1-piperidyl)-4'-alkylthiopropiophenone series, four compounds of 1-(p-alkylthiophenyl)-1-phenyl-3-(1-piperidyl)-1-propanol series, and seven compounds of 1-alkyl-1-(p-alkylphenyl)-3-(1-piperidyl)-1-propanol series were synthesized and their antiviral activities were tested. Several compounds of these series were found to be effective on the PR-8 strain of influenza A virus in chorioallantoic membrane, especially, 3-(1-piperidyl)-4'-octylthiopropiophenone and 1-cyclohexyl-1-(p-tolyl)-3-(1-piperidyl)-1-propanol. Several compounds of these series showed in vivo effect on the Nakayama strain of Japanese B encephalitis virus.抄録全体を表示PDF形式でダウンロード (703K) -
古川 潮, 瀬戸 淑子, 豊島 滋1961 年 9 巻 11 号 p. 914-921
発行日: 1961/11/25
公開日: 2008/03/31
ジャーナル フリーTo find chemotherapeutic agents for influenza and polio virus and adeno virus, alkylbiguanide, arylbiguanide, 1-aryl-4, 6-diamino-1, 2-dihydro-1, 3, 5-triazine, 4-amino-6-arylamino-2-alkyl-1, 3, 5-triazine, 2, 4-diamino-5-alkyl-6-hydroxypyrimidine, and 2, 4-diamino-5-aryl-6-alkylpyrimidine were synthesized. In process of the synthesis of these compounds, it was found that the reaction of arylbiguanide with ethyl ester of carboxylic acid afforded, without the presence of alkaline catalyst, 4-amino-6-arylamino-2-alkyl-1, 3, 5-triazine. None of the compounds of this series showed activity on any of the viruses. Among these compounds, however, butyl-aned hexyl-biguanide and 1-(p-tolyl)-, 1-(o-methoxyphenyl)-, 1-(p-methoxyphenyl)-, 1-(o-ethoxyphenyl)-, and 1-(p-ethoxyphenyl)-4, 6-diamino-2, 2-dimethyl-1, 2-dihydro-1, 3, 5-triazine had inhibitory action on the growth HeLa cells.抄録全体を表示PDF形式でダウンロード (770K) -
赤堀 幸男1961 年 9 巻 11 号 p. 921-925
発行日: 1961/11/25
公開日: 2008/03/31
ジャーナル フリーThree new compounds, peucedalactone, C16H18O5, m.p. 159.0°, isopeucedalactone, C16H18O5, m.p. 122.5°, and peucin, C15H14O4, m.p. 291.5∼292.0°, were isolated from the ether extract of Peucedanum japonicum THUNB. Peucedalactone and isopeucedalactone were obtained, together with a short-chain fatty acid (p-acid), after saponification of a resinous distillate, b.p1 210∼220°, of the extract. All these three new compounds were optically active and seemed to have coumarin-like skeleton. Some of their properties were also described. Bergapten and palmitic acid were isolated besides above compounds.抄録全体を表示PDF形式でダウンロード (662K) -
津田 恭介, 飯塚 広, 佐藤 良博, 内藤 敦, 加藤 彌次1961 年 9 巻 11 号 p. 925-931
発行日: 1961/11/25
公開日: 2008/03/31
ジャーナル フリーEs wird die C1-Dehydrierungsfahigkeit von Bacillus pulvifaciens beschrieben. Reichsteins Substanz S und Hydrocortison ergeben durch Einwirkung dieser Mikroorganismen die entsprechenden C1-Dehydro-Derivate. Pregnenolon und Dehydroepiandrosteron ergeben auβer dem C1-Dehydro-Derivat noch verschiedene Umsetzungsprodukte.抄録全体を表示PDF形式でダウンロード (956K) -
佐藤 良博, 内藤 敦, 加藤 彌次, 飯塚 広, 津田 恭介1961 年 9 巻 11 号 p. 932-935
発行日: 1961/11/25
公開日: 2008/03/31
ジャーナル フリーEs wird die Methode der Strukturbestimmung der drei Umsetzungsprodukte von Dehydroepiandrosteron beschrieben. Aus der Struktur aller Umsetzungsprodukte wird entnommen, daβ Bacillus pulvifaciens auf Dehydroepiandrosteron hauptsachlich C1-dehydrierend, daneben auch 6-hydroxylierend bzw. 14-hydroxylierend wirkt.抄録全体を表示PDF形式でダウンロード (563K) -
赤堀 幸男1961 年 9 巻 11 号 p. 936-938
発行日: 1961/11/25
公開日: 2008/03/31
ジャーナル フリーThe p-acid, which was isolated from Peucedanum japonicum THUNB., was proved to be a mixture of senecioic acid, angelic acid, and a small amount of unidentified compound. Gas chromatography, ozone oxidation, NMR spectrography, and paper chromatography were used for its identification. Senecioic acid was also identified as p-bromo- and p-phenyl-phenacyl esters.抄録全体を表示PDF形式でダウンロード (442K) -
千原 呉郎, 松尾 君子, 有本 久美子, 菅野 滋子, 清水 喜八郎, 真下 啓明1961 年 9 巻 11 号 p. 939-940
発行日: 1961/11/25
公開日: 2008/03/31
ジャーナル フリーPDF形式でダウンロード (379K)
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