Summary: The localization of gamma-glutamyl transpeptidas e (gamma-GTP) activity in epithelial transitional zones, where two kinds of epithelial cells were present, was studied in normal adult rats by using the enzyme histochemical method.
Gamma-GTP activity was observed without exception in cells of the superficial layer in the squamous epithelial side the following transitional zones: esophago-gastric junction, rectoan al junction, utero-vaginal junction and the excretory duct of the laryngeal gland (stratifie d squamoussimple columnar epithelial junction); fossa navicularis and conjunctiva of the e yelid (stratified squamous-stratified columnar epithelial junction); epiglottis, junction of the nasal pharynx and epiglottis and junction of the oral pharynx and larynx (stratified squamou spseudostratified ciliated epithelial junction); and the junction between the insid e and the outside of the inner root sheath in the epithelial hair follicle.
Higher gamma-GTP activity was generally seen in the epithelial cells of transitional zones than in the neighboring epithelial cells.
As gamma-GTP activity is specific ally present in the epithelial cells of transitional zones, it is a useful marker for identifying the sites of the transitional zones. The epithelial cells in the transitional zone may undergo more extensive proliferation or perform more active functio n in the transfer of amino acids and peptides than other regular epithelial cells do.
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