By the autoradiographic techniques using
3H-deoxycytidine (
3HdCyd)and
3H-thymidine (
3HdThd), the patterns of labeling of plasma cells and pyroninophilic blast cells (immunoblasts), which are proliferating in response to antigenic stimulation, were studied in comparison with the labeling patterns of germinal-center cells.
The majority of plasma cells and immunoblasts were much more heavily labeled with
3HdThd than were the germinal-center cells. On the contrary, the ability to utilize
3HdCyd of the former two cell types was definitely inferior to that of the latter cell type. However, either plasma cells or immunoblasts were intermingled with a smaller number of cells which were as intensely labeled with
3HdCyd as were the germinal-center cells. Such cells are most likely the progenitors of plasma cells or immunoblasts.
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