Synthetic Studies of 18-Membered Antitumor Macrolide, Tedanolide. 2. Stereoselective Synthesis of the C1-C7 Fragment via a Mismatched but Highly Efficient Sharpless Dihydroxylation

Tomohiro MATSUSHIMA; Michiko MORI; Noriyuki NAKAJIMA; Hiroshi MAEDA; Jun-ichi UENISHI; Osamu YONEMITSU

doi:10.1248/cpb.46.1335

Tomohiro MATSUSHIMA, Michiko MORI, Noriyuki NAKAJIMA, Hiroshi MAEDA, Jun-ichi UENISHI, Osamu YONEMITSU

著者情報

キーワード: macrolide, stereoselective synthesis, Sharpless epoxidation, sonication, Sharpless dihydroxylation, AD-mix-α

ジャーナルフリー

1998 年 46 巻 8 号 p. 1335-1336

DOI https://doi.org/10.1248/cpb.46.1335

詳細

抄録

The C1-C7 fragment (4) of tedanolide (1) was synthesized starting from methyl (R)-3-hydroxy-2-methyl-propionate via a mismatched but highly efficient Sharpless dihydroxylation of the C1-C7 α, β-unsaturated ester (6) with AD-mix-α.

責任著者(Corresponding author)

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