Design and Synthesis of a New 4-Oxa-8ω-11-deoxy-5, 6-dihydroprostacyclin Analogue

Carlos A. M. FRAGA; Ana L. P. MIRANDA; Eliezer J. BARREIRO

doi:10.1248/cpb.44.2157

Carlos A. M. FRAGA, Ana L. P. MIRANDA, Eliezer J. BARREIRO

著者情報

キーワード: prostacyclin, stable prostacyclin analogue, antithrombotic agent, 2-oxabicyclo[3.3.0]octane derivative

ジャーナルフリー

1996 年 44 巻 11 号 p. 2157-2161

DOI https://doi.org/10.1248/cpb.44.2157

詳細

抄録

(±)-5-[5β-(((E)-1-Octen-3-ol)-1)-2-oxabicyclo[3.3.0]octan-3-yl]-4-oxapentanoic acid (±)-(1a, b), designed as a chemically and biologically stable prostacyclin analogue, was synthesized in 15% yield overall, via the (±)-3-hydroxymethyl-5-carbethoxy-2-oxabicyclo[3.3.0]octane (4) as the key intermediate.

責任著者(Corresponding author)

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