Formation of 4-p-Bromophenyl-5-hydroxy-3-methoxycarbonyl-5, 6-dihydro-4H-1, 2-oxazine by Means of New Ring Transformation of an Isoxazoline-2-oxide

Kazuho HARADA; Yuko SHIMOZONO; Eisuke KAJI; Hiroaki TAKAYANAGI; Haruo OGURA; Shonosuke ZEN

doi:10.1248/cpb.40.1921

原田和穂, 下園優子, 梶英輔, 高柳弘明, 小倉治夫, 膳昭之助

著者情報

キーワード: 2-isoxazoline-2-oxide, 5, 6-dihydro-4H-1, 2-oxazine, ring transformation, X-ray analysis, Lewis acid

ジャーナルフリー

1992 年 40 巻 7 号 p. 1921-1922

DOI https://doi.org/10.1248/cpb.40.1921

詳細

抄録

4-p-Bromophenyl-5-hydroxymethyl-3-methoxycarbonyl-2-isoxazoline-2-oxide methanesulfonate (1c) reacted with excess titanium tetrabromide in dichloromethane to yield a novel ring transformation product, 4-p-bromophenyl-5-hydroxy-3-methoxycarbonyl-5, 6-dihydro-4H-1, 2-oxazine (2). The structural determination of 2 by single-crystal X-ray analysis is reported.

責任著者(Corresponding author)

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