Synthesis and Antiarrhythmic Activity of 2, 2-Dialkyl-1'-(N-substituted aminoalkyl)-spiro-[chroman-4, 4'-imidazolidine]-2', 5'-diones

Masayuki MATSUKURA; Yoshiharu DAIKU; Kouichirou UEDA; Satoru TANAKA; Toshiji IGARASHI; Norio MINAMI

doi:10.1248/cpb.40.1823

松倉正幸, 大工嘉治, 上田耕一郎, 田中悟, 五十嵐俊二, 南法夫

著者情報

キーワード: antiarrhythmic activity, 2, 2-dialkyl-1'-(N-substituted aminoalkyl)-spiro-[chroman-4, 4'-imidazolidine]-2', 5'-dione, chloroform-induced arrhythmia, acontitine-induced arrhythmia, (-)-6-chloro-2, 2-dimethyl-1'-[3-(4-hydroxypiperidino)propyl]-spiro-[chroman-4, 4'-imidazolidine]-2', 5'-dione, spirohydantoin

ジャーナルフリー

1992 年 40 巻 7 号 p. 1823-1827

DOI https://doi.org/10.1248/cpb.40.1823

詳細

抄録

A novel series of 2, 2-dialkyl-1'-(N-substituted aminoalkyl)-spiro-[chroman-4, 4'-imidazolidine]-2', 5'-diones was synthesized and evaluated for antiarrhythmic activity in chloroform- or/and aconitine-induced ventricular arrhythmia in mice. Among these compounds, (-)-6-chloro-2, 2-dimethyl-1'-[3-(4-hydroxypiperidino)propyl]-spiro-[chroman-4, 4'-imidazolidine]-2', 5'-dione was found to be more effective than reference agents and was selected for further development.

責任著者(Corresponding author)

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