AGONIST-ANTAGONIST PROPERTIES OF 5, 7-ETHANO-4, 5, 5a, 6, 7, 11b-HEXAHYDRO-2, 6, 7-TRIMETHYL-1H-BENZO [g] HOMOQUINOLIN-9-OL AND 4, 6-ETHANO-3, 4, 4a, 5, 6, 10b-HEXAHYDRO-2, 5, 6-TRIMETHYLBENZO [f] QUINOLIN-8-OL

Mikio Hori; Tadashi Kataoka; Hiroshi Shimizu; Eiji Imai; Yoshinari Suzuki; Norihiro Kawamura; Hajime Fujimura; Masakatsu Nozaki; Masayuki Niwa

doi:10.1248/cpb.31.2520

堀幹夫, 片岡貞, 清水洋, 今井英治, 鈴木吉成, 河村典広, 藤村一, 野崎正勝, 丹羽雅之

著者情報

キーワード: stracture activity relationship

ジャーナルフリー

1983 年 31 巻 7 号 p. 2520-2522

DOI https://doi.org/10.1248/cpb.31.2520

詳細

抄録

Agonistic and antagonistic properties of novel tetracyclic benzomorphans (1-4) were evaluated in vivo and in vitro opioid receptor interaction tests. Seven-membered derivatives (1, 3) showed synergism with morphine analgesia. Six-membered derivatives (2, 4) demonstrated antagonist opioid characters.

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