The further studies for synthesis of 6-azabicyclo [3. 2. 1] octane derivatives from 1-alkyl-2 (1H)-pyridones (I) are carried out. Reaction of Ia-e with fumaric acid (II) without solvent gave 6-alkyl-7-oxo-6-azabicyclo [3. 2. 1] oct-2-ene-2, 8-endo-dicarboxylic acid (IIIa-e) and 6-alkyl-7-oxo-6-azabicyclo [3. 2. 1] oct-2-ene-2, 8-exo-dicarboxylic acid (IVa, b, d, e). Reaction of Ia-e with II in water gave IIIa-e. Reaction of Ia with maleic acid in water and without solvent afforded only IIIa.