2-Dimethylaminomethylestrone (Ia) and the 4-isomer (IIa) were obtained from the Mannich product of estrone. Methiodides of I'a-c and II'a-c were treated with alcoholic alkali to give 2-and 4-alkoxymethylestrogens in good yields. Methylation in the usual manner of I and II failed, but reaction of I and II with dimethylsulfate in a boiling methanolic alkali gave the 3-methyl ethers of 2-and 4-methoxymethylestrogens, respectively. The structural assignments of the isomers were discussed based on nuclear magnetic resonance, infrared and ultraviolet spectra.