Anthraquinone and Butenolide Constituents from the Crinoid Capillaster multiradiatus

Le Thi Vien; Tran Thi Hong Hanh; Phan Thi Thanh Huong; Nguyen Hai Dang; Nguyen Van Thanh; Nguyen Xuan Cuong; Nguyen Hoai Nam; Do Cong Thung; Phan Van Kiem; Chau Van Minh

doi:10.1248/cpb.c18-00472

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Anthraquinone and Butenolide Constituents from the Crinoid Capillaster multiradiatus

Le Thi Vien, Tran Thi Hong Hanh, Phan Thi Thanh Huong, Nguyen Hai Dang, Nguyen Van Thanh, Nguyen Xuan Cuong , Nguyen Hoai Nam, Do Cong Thung, Phan Van Kiem, Chau Van Minh

著者情報

Le Thi Vien
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
Graduate University of Science and Technology
Tran Thi Hong Hanh
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
Phan Thi Thanh Huong
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
Nguyen Hai Dang
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
Nguyen Van Thanh
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
Nguyen Xuan Cuong 責任著者
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
Graduate University of Science and Technology
Nguyen Hoai Nam
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
Do Cong Thung
Institute of Marine Environment and Resources (IMER)
Phan Van Kiem
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
Chau Van Minh
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)

キーワード: Capillaster multiradiatus, crinoid, anthraquinone, nitric oxide (NO) production, inducible nitric oxide synthase (iNOS), cyclooxygenase 2 (COX-2)

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2018 年 66 巻 11 号 p. 1023-1026

DOI https://doi.org/10.1248/cpb.c18-00472

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抄録

Seven anthraquinones including two new compounds namely capillasterquinones A and B (1 and 2) and one new butenolide namely capillasterolide (8) were isolated and structurally elucidated from the crinoid Capillaster multiradiatus. The inhibitory effect of compounds 1–8 on lipopolysaccharide (LPS)-induced nitric oxide (NO) production as well as inhibition of 1 on expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX-2) proteins in RAW264.7 cells were also evaluated. As the obtained results, capillasterquinone A (1) showed strong NO production inhibitory activity with an IC₅₀ of 5.89±0.11 µM. In addition, compound 1 reduced the LPS-induced iNOS and COX-2 expressions in a dose-dependent manner.

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