Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
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Junceols D—H, New Polyoxygenated Briaranes from Sea Whip Gorgonian Coral Junceella juncea (Ellisellidae)
Ping-Jyun SungChen-Hao PaiTsong-Long HwangTung-Yung FanJui-Hsin SuJih-Jung ChenLee-Shing FangWei-Hsien WangJyh-Horng Sheu
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2008 年 56 巻 9 号 p. 1276-1281

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Chemical investigations on the sea whip gorgonian coral Junceella juncea have led to the isolation of five new 8-hydroxybriarane diterpenoids, junceols D—H (1—5). The structures of briaranes 1—5 were determined on the basis of spectroscopic methods and the methylenecyclohexane rings were found to exist in boat form in these new diterpenoids. Junceols D (1) and F—H (3—5) exhibited cytotoxicity toward CCRF-CEM and DLD-1 tumor cells and junceols E—H (2—5) displayed weak inhibitory effects on superoxide anion generation by human neutrophils.
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© 2008 The Pharmaceutical Society of Japan
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