Prenylated Flavonoids with PTP1B Inhibitory Activity from the Root Bark of Erythrina mildbraedii

JunPil Jang; MinKyun Na; Phuong Thien Thuong; Dieudonné Njamen; Joseph Tanyi Mbafor; Zacharias Tanee Fomum; Eun-Rhan Woo; Won Keun Oh

doi:10.1248/cpb.56.85

Notes

Prenylated Flavonoids with PTP1B Inhibitory Activity from the Root Bark of Erythrina mildbraedii

JunPil Jang, MinKyun Na, Phuong Thien Thuong, Dieudonné Njamen, Joseph Tanyi Mbafor, Zacharias Tanee Fomum, Eun-Rhan Woo, Won Keun Oh

著者情報

キーワード: Erythrina mildbraedii, Leguminosae, prenyl flavonoid, protein tyrosine phosphatase 1B inhibitor

ジャーナルフリー

2008 年 56 巻 1 号 p. 85-88

DOI https://doi.org/10.1248/cpb.56.85

詳細

抄録

Phytochemical study on an EtOAc-soluble extract of the root bark of Erythrina mildbraedii resulted in the isolation of six prenylated flavonoids 1—6. Based on physicochemical and spectroscopic analyses, their structures were determined to be new natural products licoflavanone-4′-O-methyl ether (1), 2′,7-dihydroxy-4′-methoxy-5′-(3-methylbut-2-enyl)isoflavone (2), and (3R)-2′,7-dihydroxy-3′-(3-methylbut-2-enyl)-2‴,2‴-dimethylpyrano[5‴,6‴ :4′,5′]isoflavan (3), along with three known compounds erythrinin B (4), abyssinin II (5), and parvisoflavone B (6). All the isolates, except for compound 4, inhibited PTP1B activity in vitro with IC₅₀ values ranging from 5.3 to 42.6 μM. This result further suggests that the prenyl group on the B ring of flavonoids plays an important role in suppressing the enzyme PTP1B.

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