Cytotoxic Dammarane Glycosides from Processed Ginseng

Il Ho Park; Long Zhu Piao; Sung Won Kwon; Yong Jae Lee; Sool Yeon Cho; Man Ki Park; Jeong Hill Park

doi:10.1248/cpb.50.538

Notes

Cytotoxic Dammarane Glycosides from Processed Ginseng

Il Ho Park, Long Zhu Piao, Sung Won Kwon, Yong Jae Lee, Sool Yeon Cho, Man Ki Park, Jeong Hill Park

著者情報

キーワード: Panax ginseng, cytotoxicity, ginsenoside

ジャーナルフリー

2002 年 50 巻 4 号 p. 538-540

DOI https://doi.org/10.1248/cpb.50.538

詳細

抄録

Steaming ginseng at high temperature increased its cytotoxicity to SK-Hep-1 hepatoma cancer cells. HPLC separation and fractionation followed by MTT assay revealed that ginsenosides Rg₃, Rg₅, Rk₁, Rs₅, and Rs₄ are the active principles. Their 50% growth inhibition concentration (GI₅₀) values were 41, 11, 13, 37, and 13 μM, respectively. Cisplatin had a GI₅₀ of 84 μM in the same assay conditions.

責任著者(Corresponding author)

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